TGFB-Induced Factor Homeobox 1 (TGIF1) (C-Term) Peptide
TGIF1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN985031
Quick Overview for TGFB-Induced Factor Homeobox 1 (TGIF1) (C-Term) Peptide (ABIN985031)
Target
TGIF1
(TGFB-Induced Factor Homeobox 1 (TGIF1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- C-Term
-
Characteristics
- This is a synthetic peptide designed for use in combination with anti-TGIF1 antibody (Catalog #: ARP51343_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Purification
- Purified
-
-
-
-
Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Concentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handling Advice
- Avoid repeated freeze-thaw cycles.
-
Storage
- -20 °C
-
Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))
-
Background
-
TGIF1 is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.
Alias Symbols: HPE4, MGC39747, MGC5066, TGIF
Protein Interaction Partner: AR,C1orf103,CTBP1,CTBP2,EEF1A1,HDAC1,HMGB1,JUN,MAPK1,MAPK3,MED31,SIN3A,SMAD2,C1orf103,CTBP1,CTBP2,EEF1A1,FOXH1,HDAC1,JUN,MED31,MKKS,SDAD1,SMAD1,SMAD2,SMAD3,STK16
Protein Size: 401 -
Molecular Weight
- 43 kDa
-
Gene ID
- 7050
-
NCBI Accession
- NM_170695, NP_733796
-
UniProt
- Q15583
Target
-
You are here:
