Metalloproteinase Inhibitor 2 (TIMP2) (Middle Region) Peptide
TIMP2
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN985099
Quick Overview for Metalloproteinase Inhibitor 2 (TIMP2) (Middle Region) Peptide (ABIN985099)
Target
TIMP2
(Metalloproteinase Inhibitor 2 (TIMP2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein Region
- Middle Region
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Sequence
- IVPWDTLSTT QKKSLNHRYQ MGCECKITRC PMIPCYISSP DECLWMDWVT
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-TIMP2 Antibody(ARP59181_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))
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Background
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This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Alias Symbols: CSC-21K, Timp-2, Metalloproteinase inhibitor 2, TIMP2, TIMP metallopeptidase inhibitor 2, Tissue inhibitor of metalloproteinases 2, Timp2
Protein Interaction Partner: ITGA3,ITGA3,ITGB1,MMP14,MMP2,MMP8,MMP14,MMP2,PSMA7,SNCG
Protein Size: 220 -
Molecular Weight
- 22 kDa
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Gene ID
- 7077
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NCBI Accession
- NM_003255, NP_003246
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UniProt
- P16035
Target
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