Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) Peptide
TNFSF10
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN985313
Quick Overview for Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) Peptide (ABIN985313)
Target
TRAIL (TNFSF10)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-TNFSF10 antibody (Catalog #: AVARP02040_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 114-281) peptide
TNFSF10 Reactivity: Human Host: Escherichia coli (E. coli) SDS Dithiothreitol (DTT)
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
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Background
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TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
Alias Symbols: TL2, APO2L, CD253, TRAIL, Apo-2L
Protein Interaction Partner: CREBBP,HDAC1,HDAC2,HDAC3,HDAC4,HDAC5,HIST3H3,SP1,SP3,IER3,TNFRSF10B,ACP5,C7orf64,TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D,TNFRSF11B,TNFSF10,ACP5,C7orf64,TNFRSF10A,TNFRSF10B,TNFRSF10D,TNFSF10
Protein Size: 281 -
Molecular Weight
- 33 kDa
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Gene ID
- 8743
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NCBI Accession
- NM_003810, NP_003801
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UniProt
- P50591
Target
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