Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 114-281) Peptide
TNFSF10
Reactivity: Human
Host: Escherichia coli (E. coli)
SDS
Dithiothreitol (DTT)
1 image
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- Target See all TRAIL (TNFSF10) products
- TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
- Peptide Type
- Recombinant
- Protein Region
- AA 114-281
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Sequence
- MVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKIN SWESSRSGHS FLSNLHLRNG ELVIHEKGFY YIYSQTYFRF QEEIKENTKN DKQMVQYIYK YTSYPDPILL MKSARNSCWS KDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEA SFFGAFLVG
- Characteristics
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Purified recombinant Human TRAIL protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher. - Purity
- > 95 % pure
- Endotoxin Level
- < 1.0 EU per µg of protein (determined by LAL method)
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- Application Notes
- TRAIL protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Supplied as a liquid in 20 mM Tris, pH 7.5, containing 300 mM NaCl, 0.0 mM DTT, and 10 % glycerol.
- Preservative
- Dithiothreitol (DTT)
- Precaution of Use
- This product contains Dithiothreitol: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- RT/-20 °C
- Storage Comment
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- Target
- TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
- Synonyms
- APO2L Peptide, Apo-2L Peptide, CD253 Peptide, TL2 Peptide, TRAIL Peptide, A330042I21Rik Peptide, AI448571 Peptide, APO-2L Peptide, Ly81 Peptide, Trail Peptide, tl2 Peptide, apo2l Peptide, cd253 Peptide, trail Peptide, apo-2l Peptide, trail1 Peptide, xtrail1 Peptide, tnfsf10l2 Peptide, zgc:92320 Peptide, TNLG6A Peptide, TNF superfamily member 10 Peptide, tumor necrosis factor (ligand) superfamily, member 10 Peptide, tumor necrosis factor superfamily member 10 Peptide, TNF superfamily member 10 S homeolog Peptide, TNFSF10 Peptide, Tnfsf10 Peptide, tnfsf10.S Peptide, tnfsf10 Peptide
- Background
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TNF-related apoptosis-inducing ligand (TRAIL) belongs to the tumor necrosis factor (TNF) cytokine family and induces rapid apoptosis in a wide variety of tumor cell lines upon binding to the death-signalling receptors on the cell membrane. TRAIL binds to one of four receptors that have been identified in humans, including TRAIL-R1/DR4, TRAIL-R2/KILLER/DR5, TRAIL-R3/DcR1/TRID, and TRAIL-R4/DcR2/TRUNDD. Both DR4 and DR5 are pro-apoptotic receptors, which contain a cytoplasmic death domain and mediate apoptosis on binding to TRAIL. By contrast, TRID and TRUNDD do not contain a cytoplasmic death domain and block the function of TRAIL by competing with DR4 and DR5 for binding of TRAIL. Recombinant human TRAIL was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: TNFSF10 protein, TRAIL protein, Apo-2 ligand protein, TL2 protein, member 10, Tumor necrosis factor ligand superfamily protein, Tumor necrosis factor (ligand) superfamily protein, CD253 protein, member 10 protein, APO2L protein - Molecular Weight
- 23 kDa (211 AA)
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