Slow Skeletal Troponin T (TNNT1) (Middle Region) Peptide
TNNT1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN985344
Quick Overview for Slow Skeletal Troponin T (TNNT1) (Middle Region) Peptide (ABIN985344)
Target
TNNT1
(Slow Skeletal Troponin T (TNNT1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-TNNT1 antibody (Catalog #: ARP42120_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TNNT1 (Slow Skeletal Troponin T (TNNT1))
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Background
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TNNT1 is a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year.This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: ANM, MGC104241, TNT, STNT, TNTS
Protein Interaction Partner: BMPR1B,CCDC85B,FXR2,NINL,PLEKHF1,PNMA1,PPFIA1,PRKG1,PSMC5,SMAD1,SMAD2,SMURF1,TGFBR1,TNNC1,TNNI1,TNNI2,TNNI3,TNNT1,TPM1,ZMYND19,CCDC85B,FXR2,NINL,PLEKHF1,PPFIA1,PRKG1,PSMC5,TNNC1,TNNT1,TPM1,ZMYND19
Protein Size: 278 -
Molecular Weight
- 33 kDa
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Gene ID
- 7138
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NCBI Accession
- NM_003283, NP_003274
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UniProt
- P13805
Target
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