Tripartite Motif Containing 11 (TRIM11) (C-Term) Peptide
TRIM11
Reactivity: Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN985480
Quick Overview for Tripartite Motif Containing 11 (TRIM11) (C-Term) Peptide (ABIN985480)
Target
TRIM11
(Tripartite Motif Containing 11 (TRIM11))
Origin
Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- GSFYNSNEPA FSPLRDPPKR VGIFLDYEAG HLSFYSATDG SLLFIFPETL
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Trim11 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TRIM11 (Tripartite Motif Containing 11 (TRIM11))
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Background
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Trim11 is an E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. It may also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. It may contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. It mediates MED15 ubiquitination leading to proteasomal degradation. Trim11 may contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. Trim11 may regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
Alias Symbols: -
Protein Size: 467 -
Molecular Weight
- 52 kDa
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Gene ID
- 94091
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NCBI Accession
- NM_053168, NP_444398
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UniProt
- Q99PQ2
Target
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