Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3) (Middle Region) Peptide
UBE2L3
Reactivity: Human
Host: Synthetic
BP, IHC, WB
Catalog No. ABIN985828
Quick Overview for Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3) (Middle Region) Peptide (ABIN985828)
Target
UBE2L3
(Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-UBE2L3 antibody (Catalog #: ARP43023_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))
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Background
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UBE2L3 catalyzes the covalent attachment of ubiquitin to other proteins.It mediates the selective degradation of short-lived and abnormal proteins. UBE2L3 functions in the E6/E6-AP-induced ubiquitination of p53/TP53.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: E2-F1, L-UBC, UBCH7, UbcM4
Protein Interaction Partner: UBE3A,ARIH1,ARIH2,BRCA1,CBL,CCNB1IP1,CUL9,NEDD4,NEDD4L,PARK2,PTEN,RNF144A,RNF144B,RNF19A,RNF216,SMAD4,UBE3A,UBOX5,ARIH1,ARIH1,ARIH2,ARIH2,AURKA,BRCA1,CBL,CBL,CUL9,EIF4E2,ITCH,NEDD4,POLR2A,PTEN,RNF19A,RNF216,RSP5,SMURF2,UBASH3A,UBE3A,UBOX5,Ubox5,WWP2
Protein Size: 154 -
Molecular Weight
- 18 kDa
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Gene ID
- 7332
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NCBI Accession
- NM_003347, NP_003338
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UniProt
- Q5R5I4
Target
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