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Lysine (K)-Specific Demethylase 6A (KDM6A) (Middle Region) Peptide

KDM6A Reactivity: Human Host: Synthetic BP, WB

Catalog No. ABIN986013

Quick Overview for Lysine (K)-Specific Demethylase 6A (KDM6A) (Middle Region) Peptide (ABIN986013)

Target

KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Origin

Human

Source

Synthetic

Application

Blocking Peptide (BP), Western Blotting (WB)

Protein Region

Middle Region

Characteristics

This is a synthetic peptide designed for use in combination with anti-UTX antibody (Catalog #: ARP39483_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.

Purification

Purified
Lysine (K)-Specific Demethylase 6A (KDM6A) peptide
KDM6A Reactivity: Mammalian Host: Synthetic BP, WB, IHC

Lysine (K)-Specific Demethylase 6A (KDM6A) (N-Term) peptide
KDM6A Reactivity: Human Host: Synthetic BP, WB

Lysine (K)-Specific Demethylase 6A (KDM6A) (N-Term) peptide
KDM6A Reactivity: Mouse Host: Synthetic BP, WB

Application Notes

Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions

For Research Use only
Format

Lyophilized

Reconstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Concentration

1 mg/mL

Buffer

Final peptide concentration is 1 mg/mL in PBS.

Handling Advice

Avoid repeated freeze-thaw cycles.

Storage

-20 °C

Storage Comment

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Background

UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.

Alias Symbols: DKFZp686A03225, MGC141941, bA386N14.2, UTX, KABUK2

Protein Interaction Partner: SMAD9,TLE1,ASH2L,C13orf23,HIST3H3,MLL2,MLL3,N4BP2,NCOA6,PAXIP1,PPP6R3,RBBP5,TLE1,WDR5,ZNF281

Protein Size: 1401

Molecular Weight

154 kDa

Gene ID

7403

NCBI Accession

NM_021140, NP_066963

UniProt

O15550

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