zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) (N-Term) Peptide
ZAP70
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN986321
Quick Overview for zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) (N-Term) Peptide (ABIN986321)
Target
ZAP70
(zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- MRKKQIDVAI KVLKQGTEKA DTEEMMREAQ IMHQLDNPYI VRLIGVCQAE
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ZAP70 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
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Background
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This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Alias Symbols: FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Protein Interaction Partner: CRK,CRK,CRKL,ZAP70,ABL1,ACP1,CARD11,CBL,CBLB,CD247,CD3E,CD5,CD79B,CRK,DBNL,DEF6,DUSP3,FCGR3A,FCRL3,FYN,GAB2,GRB2,IFNAR1,LAT,LAX1,LCK,LCP2,MUC1,NFAM1,PAG1,PLCG1,PRLR,PTK2B,PTPN22,PTPN3,PTPN6,PTPRC,RASA1,SH2B3,SH3BP2,SHB,SHC1,SIT1,SLA,SLA2,SLAMF6,SOS1,TUBA4
Protein Size: 312 -
Molecular Weight
- 34 kDa
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Gene ID
- 7535
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NCBI Accession
- NM_207519, NP_997402
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UniProt
- P43403
Target
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