Zyxin (ZYX) (Middle Region) Peptide
ZYX
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN987257
Quick Overview for Zyxin (ZYX) (Middle Region) Peptide (ABIN987257)
Target
ZYX
(Zyxin (ZYX))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ZYX antibody (Catalog #: ARP34388_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ZYX (Zyxin (ZYX))
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Background
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TRIM50 is an E3 ubiquitin-protein ligase.Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
Alias Symbols: ESP-2, HED-2
Protein Interaction Partner: ACTN1,ATXN1,BSPRY,ENAH,HIPK3,LASP1,LATS1,NEBL,NEDD9,RPH3AL,TES,VASP,VAV1,VAV3,ZNF384,ACTN1,BCAR1,ENAH,LASP1,LATS1,NEBL,NEDD9,TES,VASP,ZHX1
Protein Size: 572 -
Molecular Weight
- 61 kDa
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Gene ID
- 7791
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NCBI Accession
- NM_003461, NP_003452
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UniProt
- Q15942
Target
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