Zyxin (ZYX) (Middle Region) Peptide
ZYX
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ZYX products
- ZYX (Zyxin (ZYX))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ZYX antibody (Catalog #: ARP34388_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ZYX (Zyxin (ZYX))
- Background
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TRIM50 is an E3 ubiquitin-protein ligase.Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
Alias Symbols: ESP-2, HED-2
Protein Interaction Partner: ACTN1,ATXN1,BSPRY,ENAH,HIPK3,LASP1,LATS1,NEBL,NEDD9,RPH3AL,TES,VASP,VAV1,VAV3,ZNF384,ACTN1,BCAR1,ENAH,LASP1,LATS1,NEBL,NEDD9,TES,VASP,ZHX1
Protein Size: 572 - Molecular Weight
- 61 kDa
- Gene ID
- 7791
- NCBI Accession
- NM_003461, NP_003452
- UniProt
- Q15942
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