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AKT1 (show AKT1 Proteins) and AKT2 isoforms have opposing roles in smooth muscle cell proliferation, migration, differentiation, and rapamycin response in vitro and in vascular injury in vivo.
IRF5 (show IRF5 Proteins) and IRF5 (show IRF5 Proteins) disease-risk variants increase glycolysis and human m1 macrophage polarization by regulating proximal signaling and Akt2 activation.
Deficiency of AKT2 in myocardium results in diminished MEF2A (show MEF2A Proteins) abundance, which induced decreased size of cardiomyocytes. We additionally confirmed that EndoG (show ENDOG Proteins), which is also regulated by AKT2, is a suppressor of MEF2A (show MEF2A Proteins) in myocardium.
Results indicate that AKT2 modulates pulmonary fibrosis through inducing TGF-beta1 (show TGFB1 Proteins) and IL-13 (show IL13 Proteins) production by macrophages, and inhibition of AKT2 may be a potential strategy for treating Idiopathic pulmonary fibrosis.
Sirt1 (show SIRT1 Proteins) significantly reduced the levels of raptor (show RPTOR Proteins) and inactivated mammalian target of rapamycin (mTOR (show FRAP1 Proteins))C1 signal by interacting with Akt2.
This review summarises and discusses the consequences of genetic deletions of Akt (show AKT1 Proteins) isoforms in adult mice and their implications for cancer therapy. Whereas combined Akt1 (show AKT1 Proteins) and Akt2 rapidly induced mortality, hepatic Akt (show AKT1 Proteins) inhibition induced liver injury that promotes hepatocellular carcinoma.
Rac1 activation is caused by membrane translocation of a guanine nucleotide exchange factor (show ARHGEF12 Proteins) FLJ00068 in Akt2-mediated insulin (show INS Proteins) signaling in mouse skeletal muscle.
BAY 1125976 is a potent and highly selective allosteric AKT1 (show AKT1 Proteins)/2 inhibitor.
AKT2 inhibition induces a unique mitochondrial-dependent DNA degradation pathway by activating nucleus translocation of AIF (show AIFM1 Proteins) and EndoG (show ENDOG Proteins) during cardiac ischemia.
Akt2 ablation may protect against paraquat toxicity-induced cardiac contractile defect and apoptosis possibly via regulation of Nrf2 (show NFE2L2 Proteins) activation and mitochondrial homeostasis.
miR296 is downregulated in tissue from patients with pancreatic cancer and pancreatic carcinoma cell lines. These findings suggested that it may function as a tumor suppressor via inhibiting the growth, migration and invasion of pancreatic cancer cells. AKT2 was validated as a direct target of miR296 in pancreatic cancer cells.
miR (show MLXIP Proteins)-143-3p acts as a novel tumor suppressive miRNA by regulating gastric tumor growth, migration and invasion through directly targeting AKT2 gene
Our findings suggest that Akt2 might be associated with the resistance to anti-EGFR (show EGFR Proteins) therapies, especially the use of erlotinib against PC, and that this resistance can be overcome by combined treatment with a PI3K (show PIK3CA Proteins) inhibitor. Akt2 expression could become a predictive biomarker for erlotinib resistance in PC.
Studied action of linoleic acid (LA) on cell migration and neoplasm invasiveness of breast cancer cells. Findings show Akt2 activation requires EGFR (show EGFR Proteins) and PI3K (show PIK3CA Proteins) activity, whereas migration and invasion are dependent on FFAR4, EGFR (show EGFR Proteins) and PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) activity.
Analysis of genomic data from TCGA demonstrated coamplification of CCNE1 (show CCNE1 Proteins) and AKT2 Overexpression of Cyclin E1 (show CCNE1 Proteins) and AKT (show AKT1 Proteins) isoforms, in addition to mutant TP53 (show TP53 Proteins), imparted malignant characteristics in untransformed fallopian tube secretory cells, the dominant site of origin of high-grade serous ovarian cancer
Akt1 (show AKT1 Proteins)-Akt3 (show AKT3 Proteins) activity (according to Thr308 phosphorylation) is not associated with proliferative processes in the tumor tissue of the thyroid.
Recent studies reveal that AKT2-NOX2 (show CYBB Proteins) signaling has critical roles in Ca mobilization, ROS (show ROS1 Proteins) generation, degranulation, and control of the ligand-binding function of cell surface molecules, thereby promoting heterotypic cell-cell interactions in thromboinflammation.
The expression levels of AKT2 and CDC25C (show CDC25C Proteins) showed lower expression in neural tube defects. And the percentage of methylated region of AKT2 promoter were increased in neural tube defects.
Report frequency of genetic variation in Akt2 and discuss link to type 2 diabetes.
Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis.
Study reports that Appl1 (show APPL1 Proteins) regulates the activity of Akt (show AKT1 Proteins) and, importantly, its downstream signaling specificity from an endosomal compartment, with profound implications for development.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
akt2 has a role in an integrative pathway directly linking glucose, Glut1 (show SLC2A1 Proteins) expression, and activation of apoptosis
Profilin (show PFN1 Proteins)-dependent dissociation of G-actin (show ACTB Proteins)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK (show ILK Proteins)) in the lamellipodia.
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
v-akt murine thymoma viral oncogene homolog 2
, RAC-beta serine/threonine-protein kinase
, AKT2 kinase
, RAC-beta serine/threonine-protein kinase-like
, serine/threonine protein kinase
, PKB beta
, RAC-beta serine/threonine protein kinase
, protein kinase Akt-2
, protein kinase B beta
, protein kinase B, beta
, murine thymoma viral (v-akt) homolog-2
, rac protein kinase beta
, RAC protein kinase beta RAC-PK beta
, murine thymoma viral (v-akt) oncogene homolog 2
, thymoma viral proto-oncogene 2
, PKB beta-A
, RAC-beta serine/threonine-protein kinase A
, protein kinase Akt-2-A
, protein kinase B, beta-A
, protein kinase B