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AMBRA1 regulates mitophagy through a novel pathway, in which HUWE1 and IKKalpha are key factors, shedding new lights on the regulation of mitochondrial quality control and homoeostasis in mammalian cells.
evidence that DCNL5 may be involved in innate immunity, as it is a direct substrate of the kinase IKKalpha during immune signalling.
cFLIP appears to bind to IKKalpha to prevent IKKalpha from phosphorylating and activating IRF7.
functions as a suppressor of lung adenocarcinoma; deletion up-regulates NOX2 and down-regulates NRF2, leading to ROS accumulation and blockade of cell senescence induction
HOTAIR operates the action of IKKalpha, IKKbeta, IKKgamma in liver cancer stem cells
Results indicate the involvement of IKK and NF-kappaB signaling in the maintenance of glioblastoma stem cell.
Loss-of-function of LINC00473 in vivo effectively promoted the regression of Wilms tumour via miR-195/IKKalpha-mediated growth inhibition.
Study results provide new insights into the molecular mechanisms of maspin suppression in response to HBx, and revealed nuclear IKKalpha as a prognostic biomarker and a potential therapeutic target to improve the clinical outcome of HBV-associated HCC patients.
Data show that IKKalpha directly bind to the promoters of LGR5, in turn, upregulating LGR5 expression through activation of STAT3 signaling pathway during cancer progression.
single-particle cryoelectron microscopy (cryo-EM) and X-ray crystal structures of human IKK1 in dimeric ( approximately 150 kDa) and hexameric ( approximately 450 kDa) forms, are reported.
results suggest that changes in the relative concentrations of RelB, NIK:IKK1, and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100.
IKKalpha-dependent phosphorylation of S376 stimulated whereas IKKalpha-independent phosphorylation of S484 inhibited RORgammat function in Th17 differentiation.
Akt2, Erk2, and IKK1/2 phosphorylate Bcl3, converting Bcl3 into a transcriptional coregulator by facilitating its recruitment to DNA.
IKKalpha promotes migration through dynamic interactions with the EGF promoter depending on the redox state within cells.
the dual regulation of STAT1 by IKKalpha in antiviral signaling suggests a role for IKKalpha in the fine-tuning of antiviral signaling in response to non-self RNA.
In epithelial ovarian cancer cells, miR-23a enhances the expression of IKKalpha. The proliferation, migration, and invasion of EOC cells are increased by IKKalpha.
TLR signaling led to lower expression of LRRC14.
IKKalpha is an important determinant of poor outcome in patients with ER-positive invasive ductal breast cancer and thus may represent a potential therapeutic target
The molecular mechanisms involved in IKKalpha-related tumors. [review]
this study shows that miR-23a regulated IL-17-mediated proinflammatory mediators expression in rheumatoid arthritis by directly targeting IKKalpha
Pathological activation of hepatic IKK alpha likely blocks hepatocyte replication, contributing to liver disease progression.
By modulating the translation of IkappaBalpha via the Mnk2-eIF4E pathway, Brd4 provides an additional layer of control for NF-kappaB-dependent inflammatory gene expression and inflammatory response.
UVB-irradiated or aged mice skin revealed that mTORC2 activity was significantly upregulated which in turn increased Akt activation and Akt-dependent IkappaB kinase alpha (IKKalpha) phosphorylation, and The increased mTORC2 signaling pathway during skin aging were associated to NF-kappaB activation.
Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkalpha and Irf6.
IKKalpha as a central mediator sensing both cytokine and microbial stimulation to suppress endoplasmic reticulum stress, thereby assuring antiinflammatory function during acute intestinal inflammation.
The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1.
Data indicate that the inflammation and proliferation-related functions of I kappa B kinase (IKKbeta) can be uncoupled by quinoxaline urea analog 13-197.
Hematopoietic IKKalpha deficiency in mouse suppresses Akt signaling, compromising monocyte/macrophage survival and this decreases early atherosclerosis.
Anatomy of a negative feedback loop: the case of IkappaBalpha.
Epithelial-intrinsic IKK-alpha expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.
IKKalpha mediated the repair of the kidney via infiltrated regulatory T (Treg) cells, which can produce anti-inflammatory cytokine IL10
phosphorylation of DBC1 at its C terminus by IKKalpha facilitates its interaction with RelB and IKKalpha, indicating that DBC1-mediated suppression of alternative NF-kappaB is regulated by IKKalpha.
IKKalpha controls the inflammasome at the level of the adaptor molecule ASC, which interacts with IKKalpha in the nucleus of resting macrophages in an IKKalpha kinase-dependent manner.
Stimulated BTK-deficient dendritic cells are defective in the induction of IKK alpha/beta phosphorylation and IRF-1 activation.
IKKalpha has a role in the maintenance of a normal Treg population and in the control of expansion of CD4 T cells
TCR-stimulated activation of NF-kappaB requires the assembly of cytosolic p62-Bcl10-Malt1-IKK signalosomes, which may ensure highly regulated activation of NF-kappaB in response to TCR engagement.
These findings reveal a molecular mechanism regulating migration and invasion of epithelial cells and establish a key direct link between IKKbeta and cell motility controlled by Rap-integrin signaling.
poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis
Ikk1 negatively regulates NF-kappaB by sequestering NEMO from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB.
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
, i kappa-B kinase alpha
, inhibitor of nuclear factor kappa-B kinase subunit alpha
, nuclear factor NF-kappa-B inhibitor kinase alpha
, SPFH domain-containing protein 1
, conserved helix-loop-helix ubiquitous kinase
, I-kappa-B kinase 1
, I-kappa-B kinase-alpha
, IKK-a kinase
, IkB kinase alpha subunit
, Nuclear factor NFkappaB inhibitor kinase alpha
, transcription factor 16
, I kappa B kinase 1
, I-kappa-B kinase alpha
, IKK alpha
, IkappaB kinase alpha
, ikappaB kinase
, IkB kinase-a