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anti-Rat (Rattus) Raptor Antibodies:
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Human Polyclonal Raptor Primary Antibody for WB - ABIN151797
Williamson, Kubica, Kimball, Jefferson: Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. in The Journal of physiology 2006
Show all 6 Pubmed References
Human Monoclonal Raptor Primary Antibody for ELISA, WB - ABIN1724920
Sun, Southard, Witonsky, Kittler, Di Rienzo: Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations. in PLoS genetics 2010
Show all 2 Pubmed References
We found that neither S6K (show RPS6KB1 Antibodies)-dependent cell growth nor S6K (show RPS6KB1 Antibodies)-Thr (show TRH Antibodies)-398 phosphorylation was affected in rictor (show RICTOR Antibodies)-null mutants.
data reveal that RAPTOR up-regulation contributes to PI3K (show PIK3CA Antibodies)-mTOR (show FRAP1 Antibodies) inhibitor resistance, and suggest that RAPTOR expression should be included in the pharmacodynamic assessment of mTOR (show FRAP1 Antibodies) kinase inhibitor trials
Hypomethylation of CpG sites in RPTOR, MGRN1 (show MGRN1 Antibodies) and RAPSN (show RAPSN Antibodies) in blood is associated with breast cancer.
RPTOR (regulatory associated protein of mTOR, complex 1) is a novel target of miR (show MLXIP Antibodies)-155 in CF lung epithelial cells. The suppression of RPTOR expression and subsequent activation of TGF-beta (show TGFB1 Antibodies) signaling resulted in the induction of fibrosis by elevating connective tissue growth factor (CTGF (show CTGF Antibodies)) abundance in CF lung epithelial cells.
Data show that mTOR (show FRAP1 Antibodies) protein forms a complex with Raptor and estrogen receptor-alpha (ERalpha (show ESR1 Antibodies)).
Up-regulation of mTORC1 via raptor by aldosterone is a critical pathobiologic mechanism that controls pulmonary artery smooth muscle cell survival to promote hypertrophic vascular remodeling and pulmonary arterial hypertension.
Hgh mTOR (show FRAP1 Antibodies) activity and Rictor (show RICTOR Antibodies) overexpression could be markers of a bad prognosis. Combined phosphoprotein and Rictor (show RICTOR Antibodies)/Raptor expression evaluation revealed even stronger statistical correlation with prognosis.
revealed more than 170 NFAT (show NFATC1 Antibodies)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (show NFATC1 Antibodies) and NFATc2 (show NFAT1 Antibodies) in T cells, such as Raptor, CHEK1 (show CHEK1 Antibodies), CREB1 (show CREB1 Antibodies), RUNX1 (show RUNX1 Antibodies), SATB1 (show SATB1 Antibodies), Ikaros (show IKZF1 Antibodies), and Helios (show ZNFN1A2 Antibodies).
In this study we began by validating the expression of four main mTOR (show FRAP1 Antibodies) pathway components, mTOR (show FRAP1 Antibodies), DEPTOR (show DEPTOR Antibodies), rictor (show RICTOR Antibodies) and raptor, at gene and protein level in in vitro models of endometrioid (MDAH2774) and clear cell (SKOV3) ovarian cancer
Our results demonstrate for the first time that the expression quantitative trait loci of RPTOR, rs7502563, is susceptible to glioma
The positive regulation of mTORC1 activity by NPRL2 (show NPRL2 Antibodies) is mediated through NPRL2 (show NPRL2 Antibodies) interaction with Raptor.
Thus, the various regulatory elements that impinge upstream of mTORC1 activation pathways are differentially required for HSC (show FUT1 Antibodies) homeostasis in vivo.
Deletion of Raptor reduced the size of limb bud cells, resulting in overall diminution of the limb bud without affecting skeletal patterning. We then examined the potential role of mTORC1 in chondrogenic differentiation in vitro.
Results provide genetic evidence indicating that mTOR (show FRAP1 Antibodies) and Raptor are required for sensory axon regeneration enhanced by peripheral lesions in mice, whereas Rictor (show RICTOR Antibodies) plays a minor role. The peripheral lesion activates rapamycin-resistant mTOR (show FRAP1 Antibodies) signaling to modulate Stat3 (show STAT3 Antibodies) activity and further promotes axon regeneration.
This study demonstrated that Loss of the Rptor gene in mice neural progenitor cells affects normal development in young age and may contribute to alleviate KA seizure-induced behavioral abnormalities, suggesting that raptor protein plays an important role in seizure comorbidities.
These results demonstrate that mTORC1 has an essential role in the meiotic progression and silencing of sex chromosomes in the male germline, based on conditional knockdown of its core component, Raptor.
Rptor/mTORC1 signalling supports germinal center B cell responses at both early and late GC phases during viral infection but does not regulate GCB (show NPR2 Antibodies) cell differentiation into memory B cells and plasma cells at the late GC stage.
mitochondrial dysfunction triggers LKB1 (show STK11 Antibodies)-mediated AMPK (show PRKAA1 Antibodies) activation, which stimulates Sirt2 (show SIRT2 Antibodies) phosphorylation, leading to activation of mTOR (show FRAP1 Antibodies)-RAPTOR and Glut1 (show SLC2A1 Antibodies)-mediated glucose uptake.
inhibiting regulatory-associated protein of mechanistic target of rapamycin (show FRAP1 Antibodies) (RPTOR) in hyperoxia settings, limited lung injury by increased autophagy, decreased apoptosis, improved lung architecture, and increased survival.
Raptor knockout mice are lean and insulin (show INS Antibodies) resistant with increased energy expenditure, and they are resistant to a high-fat diet.
The findings reveal HDAC5 (show HDAC5 Antibodies)-mTORC1 signaling as a novel mechanism in the differential regulation of gastric ghrelin (show GHRL Antibodies) and nesfatin-1 (show NUCB2 Antibodies).
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.
, target of rapamycin (TOR)-associated protein
, Raptor family protein
, WD40 repeat-containing protein
, armadillo-like helical domain-containing protein
, p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats
, regulatory-associated protein of mTOR
, p150 target of rapamycin (TOR)-scaffold protein