Raptor antibody (AA 874-1009)

Catalog No. ABIN1724920

This Mouse Monoclonal antibody specifically detects Raptor in ELISA. It exhibits reactivity toward Human. It has been mentioned in 2+ publications

Quick Overview for Raptor antibody (AA 874-1009) (ABIN1724920)

Target: Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Raptor antibody is un-conjugated

Application: ELISA

Clone: 6G9C4

Product Details anti-Raptor Antibody

Binding Specificity: AA 874-1009

Purpose: RPTOR Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human RPTOR (AA: 874-1009) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Raptor antibody (ABIN1724920)

Vazquez-Martin, Cufí, Oliveras-Ferraros, Menendez: "Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs)." in: Cell cycle (Georgetown, Tex.), Vol. 10, Issue 18, pp. 3140-52, (2011) (PubMed).

Sun, Southard, Witonsky, Kittler, Di Rienzo: "Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations." in: PLoS genetics, Vol. 6, Issue 10, pp. e1001178, (2010) (PubMed).

Target Details for Raptor

Target: Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))

Alternative Name: RPTOR

Background: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 149 kDa

Gene ID: 57521

UniProt: Q8N122

Pathways: PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Autophagy, BCR Signaling, Warburg Effect