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Recombinant Raptor antibody

RPTOR Reactivity: Human ELISA, IHC Host: Rabbit Monoclonal 1B10 unconjugated Recombinant Antibody
Catalog No. ABIN7127787
  • Target See all Raptor (RPTOR) Antibodies
    Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 39
    • 6
    • 3
    Human
    Host
    • 32
    • 7
    Rabbit
    Clonality
    • 33
    • 6
    Monoclonal
    Conjugate
    • 19
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Raptor antibody is un-conjugated
    Application
    • 20
    • 14
    • 10
    • 6
    • 5
    • 4
    • 3
    • 3
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    Affinity-chromatography
    Immunogen
    A synthesized peptide derived from human Raptor
    Clone
    1B10
    Isotype
    IgG
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    Discover our top product RPTOR Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))
    Alternative Name
    RPTOR (RPTOR Products)
    Synonyms
    KOG1 antibody, Mip1 antibody, 4932417H02Rik antibody, Rap antibody, Raptor antibody, mKIAA1303 antibody, RGD1311784 antibody, raptor antibody, regulatory associated protein of MTOR complex 1 antibody, regulatory associated protein of MTOR, complex 1 antibody, regulatory associated protein of MTOR, complex 1 L homeolog antibody, RPTOR antibody, Rptor antibody, rptor.L antibody, rptor antibody
    Background

    Background: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals, functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.

    Aliases: Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein), RPTOR, KIAA1303 RAPTOR

    UniProt
    Q8N122
    Pathways
    PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Autophagy, BCR Signaling, Warburg Effect
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