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Everolimus down-regulates the systemic levels of gastrin (show GAST Proteins) and glucagon in patients with pancreatic neuroendocrine tumors.
Glucagon-like peptide (GLP-2) stimulates cancer myofibroblast proliferation, migration and invasion; GLP-2 acts indirectly on epithelial cells partly via increased Insulin (show INS Proteins)-like growth factor (IGF) expression in myofibroblasts.
Describe model, in which the release of GIP (show GIP Proteins)/GLP-1 is stimulated by glucose in the proximal small intestine, and no differences in the secretion dynamics between healthy individuals and patients with T2D are identified after taking differences in glucose profiles into account.
the solvent exposure of the two Phe sites along the glucagon sequence was determined, showing that 4F-Phe6 was fully solvent exposed and 4F-Phe22 was only partially exposed
Data suggest that dose/intensity-response relationships exist between exercise intensity and total plasma PYY levels, though the effects on total plasma GLP1 levels and hunger perceptions seem unclear. (PYY = peptide YY ; GLP1 = glucagon-like peptide 1)
GLP-2 could be considered an hormone causing positive energy balance, which, however has the role to mitigate the metabolic dysfunctions associated with hyper-adiposity. [review]
Studies indicate that nutrient-induced glucagonlike peptide-1 (GLP-1) response was one of the best predictors of type 2 diabetes mellitus (T2DM) remission after Roux-en-Y-gastric-bypass (RYGB).
Insulin (show INS Proteins) resistance in non-diabetic individuals is associated with raised fasting GLP-1 levels but reduced GLP-1 responses to meal stimulation.
we saw that GLP-1 induces phosphorylation of the epidermal growth factor receptor (show EGFR Proteins) and activation of Foxo1 (show FOXO1 Proteins), resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase (show AMY Proteins) and lipase (show LIPG Proteins) levels in subjects treated with GLP-1 receptor (show GLP1R Proteins) agonists reflect adaptive growth rather than early-stage pancreatitis.
Age-dependent human beta cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
Glucokinase (show GCK Proteins) governs an alpha-cell metabolic pathway that suppresses secretion at or above normoglycemic levels; abnormal suppression of glucagon secretion deregulates hepatic glucose metabolism and, over time, induces a pre-diabetic phenotype.
in colonic crypt cultures, the GLP-1 secretion induced by such Gq + Gs GPR40 agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these.
Enteric GLP-1 activates NO production by enteric neurons that is impaired in type 2 diabetes. Gut (show GUSB Proteins) microbiota dysbiosis induces enteric neuropathy. Gut (show GUSB Proteins) microbiota dysbiosis is responsible for the GLP-1 resistance.
of glucagon-like peptide-1 in vagotomized mice may prevent VLDL overproduction and insulin (show INS Proteins) resistance induced by high-fat diet.
beta-cell function, plasma active GLP-1 levels, the GLP-1R (show GLP1R Proteins) pathway in beta cells and L cell differentiation, were investigated.
CCK (show CCK Proteins)/GLP-1 play contributory roles in anorexia induction by trichothecenes T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol.
The role of syntaxin 1A (show STX1A Proteins) in GLP1 release from intestinal cells as a response to external stimuli is reported.
GCG neurons likely stimulate separate populations of downstream cells to produce a change in food intake and glucose homeostasis and that these effects depend on the metabolic state of the animal.
Together, our data indicate effects of AgoPAMs that go beyond glucose lowering previously observed with GPR40 partial agonist treatment with additional potential for weight loss.
pancreatic reactivation of Gcg fully restored the effect of exendin-[9-39] to impair both oral and intraperitoneal glucose tolerance.
data demonstrate that cattle express proglucagon and glucagon-like peptide 2 receptor (show GLP2R Proteins) mRNA primarily in small intestinal and colon tissues and increased nutrient intake increases ileal proglucagon mRNA and plasma glucagon-like peptide 2
Data suggest that casein, safflower oil, sucrose, and sweetening agent rebaudioside A stimulate GLP1 release/secretion from enteroendocrine cells. (GLP1 = glucagon-like peptide 1, a peptide fragment derived from proglucagon)
The patterns of colocalization of the K cell marker, glucagon-like insulinotropic peptide, and L cell markers, glucagon like peptide-1 and peptide YY, in enteroendocrine cells of the small intestine and colon of mouse and pig, were investigated.
The findings indicate that the brainstem preproglucagon neuronal system is highly conserved between rat and non-human primate
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
, glucagon-like peptide 1
, glucagon-like peptide 2
, glucagon-like peptide I
, glucagon-like peptide-1
, preproglucagon B
, glucagon preproprotein
, preproglucagon A
, glucagon I
, proglucagon I