Glucagon Protein (GCG) (AA 21-180) (His tag)

Catalog No. ABIN7318536

This Recombinant Glucagon protein is expressed in HEK-293 Cells.

Quick Overview for Glucagon Protein (GCG) (AA 21-180) (His tag) (ABIN7318536)

Target: Glucagon (GCG)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 21-180

Purification tag / Conjugate: This Glucagon protein is labelled with His tag.

Purpose: Recombinant Human Glucagon/GCG Protein (His Tag)

Sequence: Arg21-Lys180

Characteristics: Recombinant Human Glucagon is produced by our Mammalian expression system and the target gene encoding Arg21-Lys180 is expressed with a 6His tag at the C-terminus.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 200 mM NaCl, 1 mM DTT, 50 % Glycerol, pH 8.0.

Preservative: Dithiothreitol (DTT)

Precaution of Use: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: Glucagon (GCG)

Alternative Name: Glucagon/GCG

Background: GCG,GLP-1,GLP-2,GRPP,Glicentin,Glicentin-Related Polypeptide,Glucagon,Glucagon-Like Peptide 1,Glucagon-Like Peptide 2,Glucagon-like Peptide 1,Incretin Hormone,OXM,OXY,Oxyntomodulin,Glucagon is a secreted protein and belongs to the glucagon family. Glucagon can be cleved into 8 chains, playing an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon can regulates blood glucose by decreasing glycolysis and increasing gluconeogenesis. In addition, Glucagon is involved in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo.

Molecular Weight:

Calculated MW: 18.6 kDa

Observed MW: 19 kDa

Gene ID: 2641

UniProt: P01275

Pathways: Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Negative Regulation of intrinsic apoptotic Signaling