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Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer.
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These data suggest that Schistosoma japonicum Sjp40 might inhibit hepatic stellate cell activation by promoting cellular senescence via SKP2/P27 signaling pathway.
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human epidermal growth factor receptor 2 (HER-2) levels, were correlated well with TSP50/p-Samd2/3 and TSP50/p27 expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer
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Furthermore, inhibition of COPS5 resulted in an elevation of Akt expression and sensitized SOC cells to Akt inhibitor MK2206. Suppression of COPS5 and Akt offers a potential strategy for the treatment of SOC.
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Loss of p27 associated with risk for endometrial carcinoma arising in the setting of obesity.
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p53 immunopositivity was more frequent in SCC (65%) than in VC (23%) (P
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The PSMD9 intronic SNPs rs74421874 (IVS3+nt460 G>A) and rs3825172 (IVS3+nt437 C>T) remain significantly associated with insomnia only when taking into account anxiety -and not depression- as covariate.
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Studies have found significant associations of the treatment response with the 26S proteasome non-ATPase subunit 9 (PSMD9), proteasome alpha type 7 subunit (PSMA7) and PSMD13 genes.
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recurrence rate of p27 and/or PTEN-negative patients was higher than that of the positive ones,that should be followed up closely after treatment
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The present study provided the first evidences that miR-1470 mediated lapatinib induced p27 upregulation by targeting c-jun.
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Staining intensities of cell cycle inhibitors p27 and p57 significantly increased in all parts of preeclamptic placentas compared to control
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PSMD9 expression predicts radiotherapy response in breast cancer.
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Expression of Hath1, Muc2, cyclin D1 and p27 in the xenograft tumors was also detected.
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Describe PSMD9 gene SNPs in linkage to generalized anxiety disorder in type 2 diabetic families.
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The PSMD9 single nucleotide polymorphism(SNP)s IVS3+nt460, IVS3+nt437, and 197G are in linkage with overweight condition and waist circumference in Italians.
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Our results suggest that tuberin and p27 are aberrantly expressed in malignant breast tissue
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Surprisingly, we found that GRP/GRP-R differentially induced expressions of p21 and p27. Silencing GRP/GRP-R decreased p21, but it increased p27 expressions in neuroblastoma cells.
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PSMD9 IVS3+nt460 A>G and +nt437 C>T and exon 5 E197G A>G single nucleotide polymorphisms studied and/or any variants in linkage disequilibrium with them are linked to depression in our type 2 diabetes Italian families.
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the PSMD9 IVS3 + nt460, IVS3 + nt437, E197G SNPs are linked via the recessive model to microvascular pathology of type 2 diabetes (T2D) in Italians
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PSMD9 gene SNPs are linked to elevated blood pressure/hypertension in Italian families with type 2 diabetes.
