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anti-Rat (Rattus) Antibodies:
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Mouse (Murine) Polyclonal CAD Primary Antibody for ELISA, ICC - ABIN4286809
Hara, Miyake, Arakawa, Kamidono, Hara: Over expression of inhibitor of caspase 3 activated deoxyribonuclease in human renal cell carcinoma cells enhances their resistance to cytotoxic chemotherapy in vivo. in The Journal of urology 2001
Show all 3 Pubmed References
Human Polyclonal CAD Primary Antibody for ICC, IF - ABIN253268
Morin, Fritsch, Mathieu, Gilbert, Guarmit, Firlej, Gallou-Kabani, Vieillefond, Delongchamps, Cabon: Identification of CAD as an androgen receptor interactant and an early marker of prostate tumor recurrence. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
Show all 2 Pubmed References
CAD dihydroorotase and aspartate transcarbamoylase domains self-assembles into dimers and trimers.
Detection of the CAD-ALK gene fusion in urine tr-DNA anticipated radiological confirmation of disease progression. Analysis of plasma ctDNA identified ALK kinase mutations that emerged during treatment with the ALK inhibitor entrectinib
This study showed that CAD deficiency co-occurrence of anaemia, anisopoikilocytosis, global developmental delay, and seizures.
Changes in glycosylation in caused by mutations in CAD.
These results establish CAD as a downstream effector of Rheb (show RHEB Antibodies) and suggest a possible role of Rheb (show RHEB Antibodies) in regulating de novo pyrimidine nucleotide synthesis
Recombinant aspartate carbamoyltransferase domain from the CAD enzyme complex forms homotrimers in solution.
The results obtained indicate that mLST8 (show MLST8 Antibodies) bridges between CAD and mTOR (show FRAP1 Antibodies), and plays a role in the signaling mechanism where CAD is regulated in the mTOR (show FRAP1 Antibodies) pathway through the association with mLST8 (show MLST8 Antibodies)
preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD
findings show that in prostate tumor cells, CAD fosters androgen receptor (show AR Antibodies) translocation into the nucleus and stimulates its transcriptional activity; in radical prostatectomy specimens, CAD expression was not correlated with proliferation markers, but a higher CAD mRNA level was associated with local tumor extension and cancer relapse
the cad gene is regulated by a nonclassical ERalpha (show ESR1 Antibodies)/Sp1 (show PSG1 Antibodies)-mediated pathway.
CAD functions as a necessary modulator of the hypertrophic response by regulating the mitogen-activated protein kinase (show MAPK1 Antibodies)-extracellular signal-regulated kinase 1/2 (show MAPK3 Antibodies) signaling pathway in the heart.
These findings suggest important posttranslational modifications requiring Cad as an unappreciated mechanism that regulates Notch (show NOTCH1 Antibodies)/Vegf (show VEGFA Antibodies) signaling during angiogenesis.
an essential role for CAD in facilitating proliferation and differentiation events in a tissue-specific manner
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
, CAD trifunctional protein
, multifunctional protein CAD
, carbamyl phosphatate synthetase 2
, carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase
, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
, CAD protein-like
, CAD protein carbamylphosphate synthetase domain
, dihydrorotate synthase