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(Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, and Dihydroorotase (CAD))
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The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq, Jul 2008].
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CAD Antibodies
High quality antibodies with extensive validation data.
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Latest Publications for our CAD products
: "Identification of CAD as an androgen receptor interactant and an early marker of prostate tumor recurrence." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, Issue 1, pp. 460-7, (2012) (PubMed).: "Phospho-ΔNp63α/SREBF1 protein interactions: bridging cell metabolism and cisplatin chemoresistance." in: Cell cycle (Georgetown, Tex.), Vol. 11, Issue 20, pp. 3810-27, (2012) (PubMed).
: "Expression of caspase-activated deoxyribonuclease (CAD) and caspase 3 (CPP32) in the cochlea of cisplatin (CDDP)-treated guinea pigs." in: Auris, nasus, larynx, Vol. 30, Issue 3, pp. 219-25, (2003) (PubMed).
: "Expression of caspase-activated deoxyribonuclease (CAD) and caspase 3 (CPP32) in the hydropic cochlea of guinea pigs - second report." in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, Vol. 259, Issue 5, pp. 257-61, (2002) (PubMed).
: "Over expression of inhibitor of caspase 3 activated deoxyribonuclease in human renal cell carcinoma cells enhances their resistance to cytotoxic chemotherapy in vivo." in: The Journal of urology, Vol. 166, Issue 6, pp. 2491-4, (2001) (PubMed).
: "TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB." in: Immunity, Vol. 7, Issue 6, pp. 831-6, (1998) (PubMed).
Synonyms and alternative names related to CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (Cad), carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad), 2410008J01Rik, AU018859, CAD, cb456, Cpad, si:dkey-221h15.3, wu:fc30c12, wu:fc33d01, wu:fc67g02, xcadProtein level used designations for CAD
- CAD protein
- CAD trifunctional protein
- multifunctional protein CAD
- carbamyl phosphatate synthetase 2
- carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase
- carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
- CAD protein-like
- CAD protein carbamylphosphate synthetase domain
- dihydrorotate synthase
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