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IKZF1 is upregulated in granulocytes, B cells, CD4- and CD8- T cells, and natural killer (NK) cells; it is downregulated in erythroblasts, megakaryocytes, and monocytes.
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The results introduce Rgag4 to the repertoire of effectors serving to couple the chromatin remodeler Ikaros with the hormonal stress response.
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Study results identify Ikaros as a key player in the early steps of dendritic cells development.
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we identified IKZF1 as a novel regulator of glucocorticoid -induced transcriptional responses and a critical determinant of glucocorticoid -mediated cell death in normal and leukemic B cells
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These data describe a novel regulatory mechanism through which STAT3 and the Ikaros zinc finger transcription factors Aiolos and Ikaros cooperate to regulate Bcl-6 expression.
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Ikaros is a transcriptional regulator required for maintaining levels of Foxo1 gene expression in naive T-cells.
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ADAMTS10 is identified as a potential functional integrator of the Ikaros-CtBP chromatin remodeling network.
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this study shows that ablation of Ikzf1 in RORgammat+ group 3 innate lymphoid cells results in increased expansion and cytokine production, and protection against infection and colitis
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Sumoylated Ikaros is less effective than unsumoylated forms at inhibiting the expansion of murine leukemic cells, and Ikaros sumoylation is abundant in human B-cell acute lymphoblastic leukemic cells, but not in healthy peripheral blood leukocytes. Our results suggest that sumoylation may be important in modulating the tumor suppressor function of Ikaros
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our results identify BTG1 as a tumor suppressor in leukemia that, when deleted, strongly enhances the risk of relapse in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia, and augments the glucocorticoid resistance phenotype mediated by the loss of IKZF1 function.
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These results indicate that Ikaros is required to limit B1 cell homeostasis in the adult.
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These results suggest that Ikaros functions as a negative regulator of follicular B cell activation.
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Ikaros functions as a guardian of B-1 lymphoid pattern, and that its absence directs the differentiation of B-1 cells into phagocytes.
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Ikaros is a fundamental regulator of PRC2 function in developing T cells.
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Ikaros/Ets1 binding has a role on Ikzf1 expression that is exerted at least through its promoter
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deletions on chromosomes 4 and 11 affecting Cdkn2a and Ikaros are a prominent feature of young adult irradiation-induced T-cell lymphoma.. tumors arising after irradiation suffer a second hit in Pten by mis-segregation or recombination
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Murine pancreatic adenocarcinoma reduces Ikaros expression and disrupts T cell homeostasis
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The Ikaros family of DNA-binding proteins are critical regulators of lymphocyte differentiation. (Review)
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mice with targeted deletion of the fourth DNA-binding zinc finger of the transcription factor Ikaros had increased IL-22-producing, but not IL-17-producing, CD4(+) T cells in the gut.
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by repressing autocrine IL-2 production, Ikaros ensures that naive CD8(+) T cells remain dependent on licensing by APCs and CD4(+) T cells, and it may therefore act as a cell-intrinsic safeguard against inappropriate CTL differentiation
