Browse our anti-IKZF1 (IKZF1) Antibodies

Full name:: anti-IKAROS Family Zinc Finger 1 (Ikaros) Antibodies (IKZF1)

On www.antibodies-online.com are 140 IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) Antibodies from 28 different suppliers available. Additionally we are shipping IKZF1 Kits (9) and IKZF1 Proteins (3) and many more products for this protein. A total of 164 IKZF1 products are currently listed.

Synonyms:: 5832432G11Rik, hik-1, hlk-1, hs.54452, ik1, Ikaros, ikzf1, LyF-1, lyf1, MGC108252, mKIAA4227, pro0758, RGD1562979, Zfpn1a1, Znfn1a1

list all antibodies	Gene Name	GeneID	UniProt
	IKZF1	10320	Q13422
	IKZF1	305501
	IKZF1	22778
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Relevant Pathways for anti-IKZF1 Antibodies

Production of Molecular Mediator of Immune Response

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Top referenced anti-IKZF1 Antibodies

Human Monoclonal IKZF1 Primary Antibody for ICS, WB - ABIN2689714 : Georgopoulos: Haematopoietic cell-fate decisions, chromatin regulation and ikaros. in Nature reviews. Immunology 2002 (PubMed)
Show all 5 Pubmed References
Human Polyclonal IKZF1 Primary Antibody for ELISA, WB - ABIN314228 : Mullighan, Goorha, Radtke, Miller, Coustan-Smith, Dalton, Girtman, Mathew, Ma, Pounds, Su, Pui, Relling, Evans, Shurtleff, Downing: Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. in Nature 2007 (PubMed)
Mouse (Murine) Polyclonal IKZF1 Primary Antibody for WB - ABIN2668752 : Zarnegar, Rothenberg: Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer. in Oncogene 2012 (PubMed)
Mouse (Murine) Monoclonal IKZF1 Primary Antibody for ChIPSeq, ChIP - ABIN2668828 : Yeung, Chung, Guess, Bell, Leinwand: Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos. in Nucleic acids research 2012 (PubMed)
Human Polyclonal IKZF1 Primary Antibody for CyTOF, FACS - ABIN4900336 : Iempridee, Reusch, Riching, Johannsen, Dovat, Kenney, Mertz: Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells. in Journal of virology 2014 (PubMed)
Human Polyclonal IKZF1 Primary Antibody for ELISA, IHC - ABIN4324147 : Loeper, Asa, Ezzat: Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation. in Cancer research 2008 (PubMed)

More Antibodies against IKZF1 Interaction Partners

Human IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) interaction partners

this study shows that alteration in Ikaros expression promotes B-1 cell differentiation into phagocytes
Our results demonstrate that the IKAROS promotes PHF2 (show PHF1 Antibodies) expression, and suggest that PHF2 (show PHF1 Antibodies) (low) expression works with the IKAROS gene deletion to drive oncogenesis of ALL
present case provides the first definitive evidence on the ability of an IKAROS heterozygous mutation to cause both immunodeficiency and NOTCH1 (show NOTCH1 Antibodies)-driven T-ALL in humans
Casein kinase II (show CSNK2A1 Antibodies), glycogen synthase kinase-3, and Ikaros mediated regulation of leukemia has been summarized. (Review)
Results found Ikaros directly binding the DNM2 (show DNM2 Antibodies) promoter and suppresses DNM2 (show DNM2 Antibodies) expression in ALL tumors and cell lines.
there is a clear distinction between loss-of-function and dominant-negative IKZF1 deletions. Affected patients should thus be monitored for minimal residual disease carefully to detect incipient relapses at an early stage and they are potential candidates for alternative or intensified treatment regimes.
IKZF1 gene deletion is associated with acute lymphoblastic leukemia.
data reveal the mechanism by which chromatin remodeling and target gene expression are regulated by Ikaros alone and in complex with HDAC1 (show HDAC1 Antibodies) in B-ALL
Ikaros regulates expression of the BCL6 (show BCL6 Antibodies)/BACH2 (show BACH2 Antibodies) axis in acute lymphoblastic leukemia cells.
high CRLF2 expression works with the IKZF1 deletion to drive oncogenesis of acute lymphoblastic leukemia

Mouse (Murine) IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) interaction partners

we identified IKZF1 as a novel regulator of glucocorticoid -induced transcriptional responses and a critical determinant of glucocorticoid -mediated cell death in normal and leukemic B cells
These data describe a novel regulatory mechanism through which STAT3 (show STAT3 Antibodies) and the Ikaros zinc finger transcription factors Aiolos (show IKZF3 Antibodies) and Ikaros cooperate to regulate Bcl-6 (show BCL6 Antibodies) expression.
Ikaros is a transcriptional regulator required for maintaining levels of Foxo1 (show FOXO1 Antibodies) gene expression in naive T-cells.
ADAMTS10 (show ADAMTS10 Antibodies) is identified as a potential functional integrator of the Ikaros-CtBP (show CTBP2 Antibodies) chromatin remodeling network.
this study shows that ablation of Ikzf1 in RORgammat+ group 3 innate lymphoid cells results in increased expansion and cytokine production, and protection against infection and colitis
Sumoylated Ikaros is less effective than unsumoylated forms at inhibiting the expansion of murine leukemic cells, and Ikaros sumoylation is abundant in human B-cell acute lymphoblastic leukemic cells, but not in healthy peripheral blood leukocytes. Our results suggest that sumoylation may be important in modulating the tumor suppressor function of Ikaros
our results identify BTG1 as a tumor suppressor in leukemia that, when deleted, strongly enhances the risk of relapse in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia, and augments the glucocorticoid resistance phenotype mediated by the loss of IKZF1 function.
These results indicate that Ikaros is required to limit B1 cell homeostasis in the adult.
These results suggest that Ikaros functions as a negative regulator of follicular B cell activation (show BLNK Antibodies).
Ikaros functions as a guardian of B-1 lymphoid pattern, and that its absence directs the differentiation of B-1 cells into phagocytes.

IKZF1 Antigen Profile

Antigen Summary

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Alternative names and synonyms associated with IKZF1

IKAROS family zinc finger 1 (IKZF1) antibody
IKAROS family zinc finger 1 (Ikzf1) antibody
IKAROS family zinc finger 1 (Ikaros) (ikzf1) antibody
IKAROS family zinc finger 1 (ikzf1) antibody

5832432G11Rik antibody
hik-1 antibody
hlk-1 antibody
hs.54452 antibody
ik1 antibody
Ikaros antibody
ikzf1 antibody
LyF-1 antibody
lyf1 antibody
MGC108252 antibody
mKIAA4227 antibody
pro0758 antibody
RGD1562979 antibody
Zfpn1a1 antibody
Znfn1a1 antibody

Protein level used designations for IKZF1

CLL-associated antigen KW-6 , DNA-binding protein Ikaros , Ikaros (zinc finger protein) , ikaros family zinc finger protein 1 , lymphoid transcription factor LyF-1 , zinc finger protein, subfamily 1A, 1 (Ikaros) , Ikaros transcription factor , KAROS family zinc finger 1 (Ikaros) , IKAROS family zinc finger 1 (Ikaros) , DNA-binding protein Ikaros-like , zinc finger protein subfamily 1A, 1

GENE ID	SPECIES
10320	Homo sapiens
305501	Rattus norvegicus
30177	Danio rerio
395974	Gallus gallus
483231	Canis lupus familiaris
541154	Bos taurus
548415	Xenopus (Silurana) tropicalis
744299	Pan troglodytes
100052437	Equus caballus
100356499	Oryctolagus cuniculus
100380614	Salmo salar
100403568	Callithrix jacchus
100436638	Pongo abelii
100475874	Ailuropoda melanoleuca
100601106	Nomascus leucogenys
22778	Mus musculus
100136762	Oncorhynchus mykiss

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Show all anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) Antibodies with Pubmed References

Human IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) interaction partners

Mouse (Murine) IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) interaction partners

Antigen Summary

Alternative names and synonyms associated with IKZF1

Protein level used designations for IKZF1