Browse our Pleckstrin Homology Domain Interacting Protein Proteins (PHIP)

Full name:: Pleckstrin Homology Domain Interacting Protein Proteins (PHIP)

On www.antibodies-online.com are 2 Pleckstrin Homology Domain Interacting Protein (PHIP) Proteins from 2 different suppliers available. Additionally we are shipping Pleckstrin Homology Domain Interacting Protein Antibodies (24) and Pleckstrin Homology Domain Interacting Protein Kits (4) and many more products for this protein. A total of 30 Pleckstrin Homology Domain Interacting Protein products are currently listed.

Synonyms:: 2810004D21Rik, 4632404O06Rik, BRWD2, DCAF14, Ndrp, PHIP, RGD1564964, Wdr11

list all proteins	Gene Name	GeneID	UniProt
	PHIP	55023	Q8WWQ0
Mouse PHIP	PHIP	83946
Rat PHIP	PHIP	315843
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Pleckstrin Homology Domain Interacting Protein Proteins (PHIP) by Origin

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Relevant Pathways for Pleckstrin Homology Domain Interacting Protein Proteins

Protein targeting to Nucleus

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Human Pleckstrin Homology Domain Interacting Protein (PHIP) interaction partners

These results provide further support for PHIP as a molecular prognostic marker of melanoma, and reveal a significant linkage between PHIP levels and ulceration.
The PHIP gene resides on 6q14.1, and although 6q loss has been observed in melanoma, the PHIP locus was preserved in melanoma cell lines and patient samples, and its overexpression was an independent adverse predictor of survival in melanoma patients.

Mouse (Murine) Pleckstrin Homology Domain Interacting Protein (PHIP) interaction partners

Systemic, plasmid-based shRNA targeting of Phip inhibited the metastatic progression of melanoma, whereas stable suppression of Phip in melanoma cell lines suppressed metastatic potential and prolonged the survival of tumor-bearing mice.
Together these results suggest that PHIP1 regulates postnatal growth in an IGF-1 (show IGF1 Proteins)/AKT (show AKT1 Proteins) pathway-independent manner.
Identification of a WD40 (show DCAF12L2 Proteins) repeat-containing isoform of Phip as a novel regulator of beta-cell growth and survival.

Pleckstrin Homology Domain Interacting Protein (PHIP) Protein Profile

Protein Summary

PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1\; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000

Alternative names and synonyms associated with Pleckstrin Homology Domain Interacting Protein (PHIP)

pleckstrin homology domain interacting protein (PHIP)
pleckstrin homology domain interacting protein (Phip)
pleckstrin homology domain interacting protein (phip)

2810004D21Rik protein
4632404O06Rik protein
BRWD2 protein
DCAF14 protein
Ndrp protein
PHIP protein
RGD1564964 protein
Wdr11 protein

Protein level used designations for PHIP

DDB1 and CUL4 associated factor 14 , IRS-1 PH domain-binding protein , PH-interacting protein , WD repeat-containing protein 11 , WD repeat domain 11 , neuronal differentiation related protein , neuronal differentiation-related protein , pleckstrin homology domain interacting protein , LOW QUALITY PROTEIN: PH-interacting protein

GENE ID	SPECIES
55023	Homo sapiens
83946	Mus musculus
472253	Pan troglodytes
474976	Canis lupus familiaris
523186	Bos taurus
100158567	Xenopus (Silurana) tropicalis
315843	Rattus norvegicus

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