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PNUTS is a bifunctional RNA encoding both PNUTS mRNA and lncRNA-PNUTS, each eliciting distinct biological functions. While PNUTS mRNA is ubiquitously expressed, lncRNA-PNUTS appears to be tightly regulated dependent on the status of hnRNP E1 (show PCBP1 Antibodies) and tumour context.
Biophysical analysis of PNUTS suggests an extended transcription factor TFIIS (show TCEA1 Antibodies)-like fold.
PNUTS was a valid target of miR (show MLXIP Antibodies)-383 and was involved in the inhibition of gammaH2AX (show H2AFX Antibodies).
PNUTS inhibits the PP1-mediated dephosphorylation of critical substrates, especially retinoblastoma protein, by blocking their binding sites on PP1.
our studies reveal PNUTS as a novel PTEN regulator and a likely oncogene (show RAB1A Antibodies).
PNUTS is identified as a new and integral component of the DNA damage response involved in DNA repair.
stimulation of PP1 (show PPA1 Antibodies) activity via siRNA mediated knockdown of its interacting protein PNUTS (Phosphatase Nuclear Targeting Subunit) leads to Rb dephosphorylation and apoptosis in cancer cells
mammalian Wdr82 functions in a variety of cellular processes; PTW/PP1 phosphatase complex (PNUTS, Tox4, Wdr82, PP1) has a role in the regulation of chromatin structure during the transition from mitosis into interphase
PNUTS has a role in protein kinase A-regulated targeting of PP1 to specific RNA-associated complexes in the nucleus
PNUTS, encoded by CAT 53 on 6p21.3, may have a role in the progression of AD.
stimulation of PP1 (show PPP1CC Antibodies) activity via siRNA mediated knockdown of its interacting protein PNUTS (Phosphatase Nuclear Targeting Subunit) leads to Rb dephosphorylation and apoptosis in cancer cells
Protein phosphatase 1 (show PPP1CB Antibodies) (PP1 (show PPP1CC Antibodies)) and GABA(C (show GABRR1 Antibodies)) receptors simultaneously bind to different domains of PNUTS, demonstrating that PNUTS crosslinks PP1 (show PPP1CC Antibodies) and GABA(C (show GABRR1 Antibodies)) receptors.
This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene.
HLA-C associated transcript 53
, MHC class I region proline-rich protein CAT53
, PP1-binding protein of 114 kDa
, phosphatase 1 nuclear targeting subunit
, protein phosphatase 1, regulatory (inhibitor) subunit 10
, serine/threonine-protein phosphatase 1 regulatory subunit 10
, putative protein phosphatase 1 nuclear targeting subunit
, HLA-C adjacent transcript 53
, protein phosphatase I