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The work demonstrates that PP1/PNUTS stabilizes chromatin-bound MYC in proliferating cells.
A -31 G to A "hot zone" putative functional noncoding variant of PPP1R10 was found in an AML patient. It perturbs the binding activities of E2F1, E2F4, ZBTB33, and TBP. SRSF1 and PPP1R10 genes are interacting partners in a protein-protein interaction network.
PNUTS is a bifunctional RNA encoding both PNUTS mRNA and lncRNA-PNUTS, each eliciting distinct biological functions. While PNUTS mRNA is ubiquitously expressed, lncRNA-PNUTS appears to be tightly regulated dependent on the status of hnRNP E1 and tumour context.
Biophysical analysis of PNUTS suggests an extended transcription factor TFIIS-like fold.
PNUTS was a valid target of miR-383 and was involved in the inhibition of gammaH2AX.
PNUTS inhibits the PP1-mediated dephosphorylation of critical substrates, especially retinoblastoma protein, by blocking their binding sites on PP1.
our studies reveal PNUTS as a novel PTEN regulator and a likely oncogene.
PNUTS is identified as a new and integral component of the DNA damage response involved in DNA repair.
stimulation of PP1 activity via siRNA mediated knockdown of its interacting protein PNUTS (Phosphatase Nuclear Targeting Subunit) leads to Rb dephosphorylation and apoptosis in cancer cells
mammalian Wdr82 functions in a variety of cellular processes; PTW/PP1 phosphatase complex (PNUTS, Tox4, Wdr82, PP1) has a role in the regulation of chromatin structure during the transition from mitosis into interphase
PNUTS has a role in protein kinase A-regulated targeting of PP1 to specific RNA-associated complexes in the nucleus
PNUTS, encoded by CAT 53 on 6p21.3, may have a role in the progression of AD.
results illustrate an involvement of the PNUTS:PP1 holoenzyme in chromosome decondensation in vitro and argue that PNUTS functions as a PP1-targeting subunit in this process
Findings suggest that PNUTS may play an important role in controlling cell death in response to cellular stresses such as hypoxia through the post-translational modification of p53 and MDM2.
reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis
the coordinated spatial and temporal regulation of LCP1 and PNUTS may be a novel mechanism to control the expression of genes that are critical for certain physiological and pathological processes.
no evidence found of association between a CAT53 polymorphism and Alzheimer's Disease (AD), but found a significant negative association of the C282Y HFE mutation with AD
Protein phosphatase 1 (PP1) and GABA(C) receptors simultaneously bind to different domains of PNUTS, demonstrating that PNUTS crosslinks PP1 and GABA(C) receptors.
This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene.
HLA-C associated transcript 53
, MHC class I region proline-rich protein CAT53
, PP1-binding protein of 114 kDa
, phosphatase 1 nuclear targeting subunit
, protein phosphatase 1, regulatory (inhibitor) subunit 10
, serine/threonine-protein phosphatase 1 regulatory subunit 10
, putative protein phosphatase 1 nuclear targeting subunit
, HLA-C adjacent transcript 53
, protein phosphatase I