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anti-Human SIX3 Antibodies:
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Zebrafish (Danio rerio) Polyclonal SIX3 Primary Antibody for ELISA - ABIN547978
Ando, Kobayashi, Tsubokawa, Uyemura, Furuta, Okamoto: Lhx2 mediates the activity of Six3 in zebrafish forebrain growth. in Developmental biology 2005
SIX3 deletions and incomplete penetrance in families affected by holoprosencephaly have been described.
Results demonstrate that Six3 silence or loss in glioma is induced by its promoter hypermethylation and Six3 down-regulation contributes to proliferation and invasion of glioma. And this process is involved in activation of Wnt/beta-catenin pathway. Six3 play a suppressor role in the initiation and progression of human glioma and potentially serve as a target for the diagnosis and treatment of human glioma.
SIX3 is a novel negative transcriptional regulator and acts as a tumor suppressor that directly represses the transcription of AURKA and AURKB in astrocytoma.
SIX2, SIX3, and SIX4 were correlated with higher TNM stages in lung neoplasms
High SIX3 expression is associated with Head and Neck Squamous Cell Carcinoma.
SIX3 may play an important role as a novel suppressor in human lung cancer.
Mutations in SIX3 is associated with holoprosencephaly.
There was a positive correlation between the severity of the brain malformation and facial features for SHH, SIX3, and TGIF, but no such correlation was found for ZIC2 mutations.
screened four known HPE genes in a Dutch cohort of 86 non-syndromic HPE index cases, including 53 family members. We detected 21 mutations (24.4%), 3 in SHH, 9 in ZIC2 and 9 in SIX3
SIX3 acts directly upstream of SHH, and the SHH pathway is a key regulator of ventral forebrain patterning and mutations are associated with schizencephaly.
A mutational screen was done to identify possible SIX3 mutations in a cohort of 149 (M:F 81:68) patients with hypopituitarism and/or midline abnormalities, falling within the spectrum of septo-optic dysplasia and holoprosencephaly.
The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas.
Six3 directly binds to geminin
Seven novel SIX3 mutations found in a cohort of Holoprosencephaly patinets.
different SIX3 mutations in HPE2 may affect different signaling pathways, and that one of these pathways may involve the nuclear receptor NOR1
Occurrence of aprosencephaly/atelencephaly and holoprosencephaly in a family with a SIX3 gene mutation.
Upregulation of Six3 expression in single progenitor cells of the embryonic telencephalon keeps them in an undifferentiated state; Six3 overexpression in mammalian brain depends strictly on the integrity of its DNA-binding domain.
role for the MTA1 as an upstream modifier of Six3 and indicate that Six3 is a direct stimulator of rhodopsin expression.
89% of putative deleterious human SIX3 mutations are significant loss-of-function alleles; a systematic comparison of bioactivities of mutant six3 proteins is demonstrated that confirms a role for six3 in causation of holoprosencephaly.
These data suggest a direct link between Six3 and Shh regulation during normal forebrain development and in the pathogenesis of holoprosencephaly.
Lhx2 may mediate an alternative or parallel pathway for control of cellular proliferation in the developing forebrain via Six3b.
lmo4b has an essential role in forebrain development as a modulator of six3 and rx3 expression, and thus indirectly influences neural cell fate commitment, cell proliferation and tissue growth in the anterior CNS.
This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2.
homeobox protein SIX3
, sine oculis homeobox homolog 3
, sine oculis homeobox homolog 6
, sine oculis-related homeobox 3 homolog
, sine oculis homeobox 3-like protein
, Sine oculis homeobox homolog 3