ICOSLG Protein (AA 19-258) (His tag)
Quick Overview for ICOSLG Protein (AA 19-258) (His tag) (ABIN1096073)
Target
See all ICOSLG ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 19-258
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Purification tag / Conjugate
- This ICOSLG protein is labelled with His tag.
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Purpose
- Recombinant Human B7-H2/ICOSLG/CD275 (C-6His)
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Sequence
- DTQEKEVRAM VGSDVELSCA CPEGSRFDLN DVYVYWQTSE SKTVVTYHIP QNSSLENVDS RYRNRALMSP AGMLRGDFSL RLFNVTPQDE QKFHCLVLSQ SLGFQEVLSV EVTLHVAANF SVPVVSAPHS PSQDELTFTC TSINGYPRPN VYWINKTDNS LLDQALQNDT VFLNMRGLYD VVSVLRIART PSVNIGCCIE NVLLQQNLTV GSQTGNDIGE RDKITENPVS TGEKNAATWS VDHHHHHH
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Characteristics
- Recombinant Human Inducible Co-Stimulator Ligand/ICOSLG produced by transfected human cells is a secreted protein with sequence (Asp19-Ser258) of Human ICOSLG fused with a polyhistidine tag at the C-terminus.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-258) (Active) protein (His-Avi Tag)
ICOSLG Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-258) (Active) protein (hFc Tag)ICOSLG Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-258) (Active) protein (Biotin,His-Avi Tag)ICOSLG Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-256) (Active) protein (His tag)ICOSLG Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 47-279) (Active) protein (His tag)ICOSLG Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-256) protein (His tag,mFc Tag)ICOSLG Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 18-135) protein (His-DYKDDDDK-Strep II Tag)ICOSLG Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 18-256) protein (His-DYKDDDDK-Strep II Tag)ICOSLG Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) protein (His tag)ICOSLG Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 20-302) protein (GST tag)ICOSLG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. -
Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
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Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
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Storage
- 4 °C/-20 °C/-80 °C
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Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. -
Expiry Date
- 3 months
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- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
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Alternative Name
- b7-h2
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Sub Type
- Fusionprotein
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Background
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Inducible Co-Stimulator Ligand (ICOSLG) belongs to the immunoglobulin superfamily. ICOSLG contains Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. ICOSLG acts as a costimulatory signal for T-cell proliferation and cytokine secretion, it also induces B-cell proliferation and differentiation into plasma cells. It could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. ICOSLG is widely expressed lymph nodes, leukocytes and spleen, detected on activated monocytes and dendritic cells.
Alternative Names: ICOS Ligand, B7 Homolog 2, B7-H2, B7-Like Protein Gl50, B7-Related Protein 1, B7RP-1, CD275, ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653 -
Molecular Weight
- 27.72 kDa
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UniProt
- O75144
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Pathways
- Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
Target
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