SH3G2 Protein (AA 1-352) (His tag)
Quick Overview for SH3G2 Protein (AA 1-352) (His tag) (ABIN1098256)
Target
See all SH3G2 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-352
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Purification tag / Conjugate
- This SH3G2 protein is labelled with His tag.
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Sequence
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MSVAGL KKQFHKATQK VSEKVGGAEG TKLDDDFKEM ERKVDVTSRA VMEIMTKTIE YLQPNPASRA KLSMINTMSK IRGQEKGPGY PQAEALLAEA MLKFGRELGD DCNFGPALGE VGEAMRELSE VKDSLDIEVK QNFIDPLQNL HDKDLREIQH HLKKLEGRRL DFDYKKKRQG KIPDEELRQA LEKFDESKEI AESSMFNLLE MDIEQVSQLS ALVQAQLEYH KQAVQILQQV TVRLEERIRQ ASSQPRREYQ PKPRMSLEFP TGDSTQPNGG LSHTGTPKPS GVQMDQPCCR ALYDFEPENE GELGFKEGDI ITLTNQIDEN WYEGMLHGHS GFFPINYVEI LVALPH -
Purification
- > 85% by SDS-PAGE
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Endophilin-A1 (SH3G2) (AA 1-352) protein (His tag)
custom-made SH3G2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Endophilin-A1 (SH3G2) (AA 1-352) protein (His tag)custom-made SH3G2 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Endophilin-A1 (SH3G2) (AA 1-279) protein (GST tag)SH3G2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Endophilin-A1 (SH3G2) (AA 1-352) protein (GST tag)SH3G2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Endophilin-A1 (SH3G2) (AA 1-352) protein (His-IF2DI Tag)SH3G2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Endophilin-A1 (SH3G2) protein (DYKDDDDK Tag)SH3G2 Origin: Human Host: Insect cells (Sf9) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Endophilin-A1 (SH3G2) protein (Myc-DYKDDDDK Tag)SH3G2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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Synonyms: Endophilin-A1, CNSA2, EEN-B1, SH3D2A, SH3P4
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- 20 mM Tris-HCl buffer ( pH 8.0) containing 10 % glycerol, 1 mM DTT, 50 mM NaCl
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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- SH3G2 (Endophilin-A1 (SH3G2))
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Alternative Name
- Endophilin A1/SH3GL2
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Background
- SH3GL2 (SH3-domain GRB2-like 2), also known as endophilin-A1, belongs to the endophilin family. It contains a BAR domain and a SH3 domain. Members of the BAR domain protein superfamily are essential elements of cellular traffic. Endophilins are among the best studied BAR domain proteins. They have a prominent function in synaptic vesicle endocytosis (SVE), receptor trafficking and apoptosis, and in other processes that require remodeling of the membrane structure. SH3GL2 a novel tumor suppressor gene in laryngeal squamous cell carcinoma (LSCC), induces apoptosis of tumor cells by regulating intra-cellular signal transduction networks. Recombinant human SH3GL2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
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Molecular Weight
- 42.5 kDa (376aa) confirmed by MALDI-TOF
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NCBI Accession
- NP_003017
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Pathways
- Neurotrophin Signaling Pathway, EGFR Downregulation
Target
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