Quick Overview for TDG Protein (His tag) (ABIN1098673)
Target
See all TDG ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This TDG protein is labelled with His tag.
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Thymine-DNA Glycosylase (TDG) (AA 1-421) protein (His tag)
custom-made TDG Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Thymine-DNA Glycosylase (TDG) (AA 1-410) protein (His tag)custom-made TDG Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Thymine-DNA Glycosylase (TDG) (AA 1-410) protein (GST tag)TDG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Comment
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Synonyms: Thymine-DNA glycosylase, G/T mismatch-specific thymine DNA glycosylase
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.5 mg/ml (determined by Bradford assay)
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Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 Urea, 10% glycerol, 0.1 M NaCl
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Storage
- 4 °C
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Storage Comment
- Avoid repeated freezing and thawing cycles.
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- TDG (Thymine-DNA Glycosylase (TDG))
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Alternative Name
- TDG
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Background
- Thymine-DNA glycosylase, also known as TDG, belongs to the TDG/mug DNA glycosylase family. TDG is a nuclear protein which corrects G/T mismatches to G/C pairs by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired thymin. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. Recombinant human TDG protein, fused to His-tag at N-terminus, was expressed in E.coli
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Molecular Weight
- 48.4 kDa (433aa)
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Pathways
- DNA Damage Repair, Chromatin Binding
Target
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