TNFRSF11A Protein (AA 31-214) (Fc Tag)
Quick Overview for TNFRSF11A Protein (AA 31-214) (Fc Tag) (ABIN1344162)
Target
See all TNFRSF11A ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Protein Characteristics
- AA 31-214
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Purification tag / Conjugate
- This TNFRSF11A protein is labelled with Fc Tag.
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Purpose
- RANK (mouse):Fc (human) (rec.)
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Specificity
- Binds to mouse and human RANKL.
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Cross-Reactivity
- Human, Mouse
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Characteristics
- Mouse RANK (aa 31-214) is fused at the C-terminus to the Fc portion of human IgG1.
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Endotoxin Level
- <0.01EU/μg purified protein (LAL test).
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Biological Activity Comment
- Inhibits mouse and human RANKL biological functions.
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Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) (AA 30-212) protein (His-DYKDDDDK-Strep II Tag)
TNFRSF11A Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) (AA 31-214) (Active) protein (hFc Tag)TNFRSF11A Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) (AA 31-130) protein (GST tag)TNFRSF11A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) protein (His tag)TNFRSF11A Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) protein (Fc Tag)TNFRSF11A Origin: Rat Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE
Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) protein (His tag)TNFRSF11A Origin: Rat Host: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE
Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) (AA 30-212) protein (Fc Tag)TNFRSF11A Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) (AA 28-202) protein (His-IF2DI Tag)TNFRSF11A Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) (AA 28-212) protein (hIgG-His-tag)TNFRSF11A Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) (AA 30-212) (Active) protein (Fc Tag)TNFRSF11A Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute with 50 μL sterile water.
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Concentration
- 1 mg/mL
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Buffer
- Contains PBS.
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Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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Expiry Date
- 6 months
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- TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))
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Alternative Name
- RANK
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Background
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TNFRSF11A, ODFR, Osteoclast Differentiation Factor Receptor, CD265
RANK (TRANCE-R, CD265) is the receptor for RANKL/TRANCE/OPGL. It is essential for RANKL-mediated osteoclastogenesis and is involved in the regulation of interactions between T cells and dendritic cells.
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Molecular Weight
- ~55kDa (SDS-PAGE)
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UniProt
- O35305
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Pathways
- NF-kappaB Signaling
Target
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