TNFRSF1A Protein (AA 22-211) (Fc Tag)
Quick Overview for TNFRSF1A Protein (AA 22-211) (Fc Tag) (ABIN1344258)
Target
See all TNFRSF1A ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Protein Characteristics
- AA 22-211
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Purification tag / Conjugate
- This TNFRSF1A protein is labelled with Fc Tag.
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Purpose
- TNF-R1 (human):Fc (human) (rec.)
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Specificity
- Binds human and mouse TNF-alpha.
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Cross-Reactivity
- Human, Mouse
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Characteristics
- The extracellular domain of human TNF-R1 (aa 22-211) is fused to the Fc portion of human IgG1.
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Endotoxin Level
- <0.01EU/μg purified protein (LAL test).
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Biological Activity Comment
- TNF-R1:Fc fusion protein blocks TNF-alpha-mediated biological effect with an inhibitory activity in a concentration range of 0.1 to 1μg/ml.
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Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 30-211) (Active) protein (His tag)
TNFRSF1A Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 30-211) (Active) protein (His tag)TNFRSF1A Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 22-211) protein (His-DYKDDDDK-Strep II Tag)TNFRSF1A Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) proteinTNFRSF1A Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 31-130) protein (GST tag)TNFRSF1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 22-212) protein (His-IF2DI Tag)TNFRSF1A Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 30-211) protein (Fc Tag)TNFRSF1A Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 30-211) protein (hIgG-His-tag)TNFRSF1A Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 22-211) protein (His tag)TNFRSF1A Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % SDS
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 1-455) protein (GST tag)TNFRSF1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute with 50 μL sterile water.
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Concentration
- 1 mg/mL
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Buffer
- Contains PBS.
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Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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Expiry Date
- 6 months
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- TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))
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Alternative Name
- TNF-R1
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Background
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p55, CD120a, TNFRSF 1A, Tumor Necrosis Factor Receptor Superfamily Member 1A, TNF Receptor 1
TNF-R1 is a receptor for TNF-alpha and homotrimeric lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
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Molecular Weight
- ~60kDa (reducing SDS-PAGE)
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UniProt
- P19438
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Pathways
- NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C, Ubiquitin Proteasome Pathway
Target
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