Annexin V Protein (Atto 488,GST tag)
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- Target See all Annexin V (ANXA5) Proteins
- Annexin V (ANXA5) (Annexin A5 (ANXA5))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Annexin V protein is labelled with Atto 488,GST tag.
- Application
- SDS-PAGE (SDS), Flow Cytometry (FACS)
- Purpose
- Annexin V (human) (rec.) (ATTO 488)
- Specificity
- Binds to phosphatidylserine (PS).
- Cross-Reactivity
- Human
- Characteristics
- Recombinant human annexin V fused to a GST-tag.
- Purity
- >95 % (SDS-PAGE)
- Top Product
- Discover our top product ANXA5 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In PBS, pH 7.4, containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Do not freeze. Protect from light.
- Storage
- 4 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: +4°C
Use & Stability: Stable for at least 1 year after receipt when stored at +4°C.
- Expiry Date
- 12 months
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- Target
- Annexin V (ANXA5) (Annexin A5 (ANXA5))
- Alternative Name
- Annexin V (ANXA5 Products)
- Background
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Annexin A5, Endonexin II, Lipocortin V, Placental Anticoagulant Protein I, Calphobindin I, Vascular Anticoagulant-alpha
Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e.g. platelets) with prothrombin or coagulation factors and inhibis the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the "annexin V affinity assay" to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.
- Molecular Weight
- ~52kDa (SDS-PAGE)
- UniProt
- P08758
- Pathways
- Apoptosis
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