MESP1 Protein
Quick Overview for MESP1 Protein (ABIN1589743)
Target
See all MESP1 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- MesP1
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Sequence
- MAQPLCPPLS ESWMLSAAWG PTRRPPPSDK DCGRSLVSSP DSWGSTPADS PVASPARPGT LRDPRAPSVG RRGARSSRLG SGQRQSASER EKLRMRTLAR ALHELRRFLP PSVAPAGQSL TKIETLRLAI RYIGHLSAVL GLSEESLQRR CRQRGDAGSP RGCPLCPDDC PAQMQTRTQA EGQGQGRGLG LVSAVRAGAS WGSPPACPGA RAAPEPRDPP ALFAEAACPE GQAMEPSPPS PLLPGDVLAL LETWMPLSPL EWLPEEPK
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Specificity
- Chromosomal location:15q26.1
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Characteristics
- Length (aa):268
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Mesoderm Posterior 1 (MESP1) (AA 1-243) protein (His tag)
custom-made MESP1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mesoderm Posterior 1 (MESP1) (AA 1-268) protein (His tag)custom-made MESP1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mesoderm Posterior 1 (MESP1) protein (Myc-DYKDDDDK Tag)MESP1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Comment
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Cytokines & Growth Factors
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Human MesP1 should be reconstituted in sterile water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.
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Buffer
- 0.5X PBS
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Handling Advice
- Freeze/thaw cycles will result in significant loss of activity.
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Storage
- RT,0 °C
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Storage Comment
- The lyophilized human MesP1, though stable at room temperature, is best stored desiccated below 0°C. Freeze/thaw cycles will result in significant loss of activity.
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- MESP1 (Mesoderm Posterior 1 (MESP1))
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Alternative Name
- MesP1
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Background
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ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1 (1,2). As one of the earliest markers, it is expressed specifically in almost all cardiovascular precursors and is required for cardiac morphogenesis (2,3). It was shown that MesP1 is a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells. Electrophysiological analysis showed all subtypes of cardiac ES-cell differentiation (4). MesP1 overexpression and knockdown experiments revealed a prominent function of MesP1 in a gene regulatory cascade, causing Dkk-1-mediated blockade of canonical Wnt-signalling. Independent evidence from ChIP and in vitro DNA-binding studies, expression analysis in wild-type and MesP knockout mice, and reporter assays confirm that Dkk-1 is a direct target of MesP1.
Synonyms: MESP1, bHLHc5 -
Molecular Weight
- 34 kDa
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Gene ID
- 55897
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NCBI Accession
- NM_018670, NP_061140
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UniProt
- Q9BRJ9
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Pathways
- Regulation of Muscle Cell Differentiation
Target
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