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C-Peptide Protein

Recombinant C-Peptide protein expressed in Escherichia coli (E. coli).
Catalog No. ABIN1880359

Quick Overview for C-Peptide Protein (ABIN1880359)

Target

See all C-Peptide Proteins
C-Peptide

Protein Type

Recombinant

Origin

  • 3
  • 1
  • 1
  • 1
  • 1
Human

Source

  • 3
  • 2
  • 2
Escherichia coli (E. coli)

Purity

> 95 % by HPLC & SDS-PAGE
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  • Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    10mM PBS (pH 7.5)

    Preservative

    Without preservative

    Storage

    4 °C
  • Target

    C-Peptide

    Background

    Connecting peptide, or C-peptide, is a short 31-amino-acid protein that connects insulin's A-chain to its B-chain in the proinsulin molecule. C-peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. It has been found to exert beneficial effects in many tissues affected by diabetic microvascular complications, including the kidneys. C-peptide at physiological concentrations effectively reduces diabetes-induced glomerular hyperfiltration via constriction of the afferent arteriole, dilation of the efferent arteriole, and inhibition of tubular reabsorption in experimental models of type 1 diabetes.
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