C-Peptide Protein
Quick Overview for C-Peptide Protein (ABIN1880359)
Target
See all C-Peptide ProteinsProtein Type
Origin
Source
Purity
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 10mM PBS (pH 7.5)
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Preservative
- Without preservative
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Storage
- 4 °C
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- C-Peptide
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Background
- Connecting peptide, or C-peptide, is a short 31-amino-acid protein that connects insulin's A-chain to its B-chain in the proinsulin molecule. C-peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. It has been found to exert beneficial effects in many tissues affected by diabetic microvascular complications, including the kidneys. C-peptide at physiological concentrations effectively reduces diabetes-induced glomerular hyperfiltration via constriction of the afferent arteriole, dilation of the efferent arteriole, and inhibition of tubular reabsorption in experimental models of type 1 diabetes.
Target
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