Myoglobin Protein (MB)

Catalog No. ABIN1880424

This Recombinant Myoglobin protein is expressed in Escherichia coli (E. coli).

Quick Overview for Myoglobin Protein (MB) (ABIN1880424)

Target: Myoglobin (MB)

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 98 % by SDS-PAGE

Product Details

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM Tris-HCl (pH 7.4) with 0.1 % NaN3.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C

Target Details

Target: Myoglobin (MB)

Alternative Name: Myoglobin

Background: Myoglobin, MB is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates in general and in almost all mammals. It is a cytoplasmic hemoprotein, expressed solely in cardiac myocytes and oxidative skeletal muscle fibers, that reversibly binds O2 by its heme residue, a porphyrin ring:iron ion complex. MB is a single-chain globular protein of 153 or 154 amino acids, containing a heme prosthetic group in the center around which the remaining apoprotein folds. Myoglobin is released from damaged muscle tissue (rhabdomyolysis), which has very high concentrations of myoglobin. The released myoglobin is filtered by the kidneys but is toxic to the renal tubular epithelium and so may cause acute renal failure. It is a sensitive marker for muscle injury, making it a potential marker for heart attack in patients with chest pain. However, elevated myoglobin has low specificity for acute myocardial infarction (AMI) and thus CK-MB, cTnT, ECG, and clinical signs should be taken into account to make the diagnosis.

Molecular Weight: 17.8 kDa

Pathways: Brown Fat Cell Differentiation