IL18BP Protein (AA 31-194)
Quick Overview for IL18BP Protein (AA 31-194) (ABIN2018075)
Target
See all IL18BP ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 31-194
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Characteristics
- ED50 < 30 ng /mL, measured in a bioassay using KG-1 cells in the presence of 50 ng/mL Human IL-18.
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Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Interleukin 18 Binding Protein (IL18BP) (AA 31-194) protein (Fc Tag)
IL18BP Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 18 Binding Protein (IL18BP) (AA 31-194) protein (His tag)IL18BP Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 18 Binding Protein (IL18BP) (AA 31-194) protein (His-Avi Tag,Biotin)IL18BP Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 18 Binding Protein (IL18BP) (AA 29-193) protein (His tag)IL18BP Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 18 Binding Protein (IL18BP) (AA 29-193) protein (Fc Tag)IL18BP Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 18 Binding Protein (IL18BP) (AA 31-194) protein (GST tag)IL18BP Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 18 Binding Protein (IL18BP) (AA 28-207) protein (Fc Tag)IL18BP Origin: Cynomolgus Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 18 Binding Protein (IL18BP) (AA 31-192) protein (Fc Tag)IL18BP Origin: Dog Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 18 Binding Protein (IL18BP) proteinIL18BP Origin: Human Host: Escherichia coli (E. coli) Recombinant SDS
Interleukin 18 Binding Protein (IL18BP) (AA 31-194) protein (hIgG-His-tag)IL18BP Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Storage
- -80 °C
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Storage Comment
- Lyophilized recombinant Human IL-18BP remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human IL-18BP should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
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Expiry Date
- 6 months
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- IL18BP (Interleukin 18 Binding Protein (IL18BP))
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Alternative Name
- Interleukin-18 Binding Protein (IL-18 BP)
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Background
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Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. It is expressed in heart, lung, placenta and spleen. IL-18BP functions as an inhibitor of the proinflammatory cytokine IL-18. It binds to IL-18, prevents the binding of IL-18 to its receptor, and thus blocks IL-18-induced IFN-gamma production. The complete Ig domain has been shown to mediate the binding and neutralizing properties. IFN-gamma is able to upregulate the expression of IL-18BP, indicating that IL-18 activity is regulated by a feedback mechanism through IL-18BP.
Synonyms: Tadekinig-alfa, IL18BP -
Molecular Weight
- 42-44 kDa, observed by reducing SDS-PAGE.
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UniProt
- O95998
Target
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