IL-19 Protein (AA 25-176)
Quick Overview for IL-19 Protein (AA 25-176) (ABIN2018081)
Target
See all IL-19 (IL19) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 25-176
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Characteristics
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ED50 < 50 ng/mL, measured by a cell proliferation assay using MCF-7 cells, corresponding to a specific activity of > 2x 10^4 units/mg.
AA 25-176, expressed with an N-terminal Met. -
Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Interleukin 19 (IL19) (Active) protein
IL19 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Interleukin 19 (IL19) (AA 25-176) protein (His tag)IL19 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 19 (IL19) (AA 1-215) protein (GST tag)IL19 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 19 (IL19) (AA 25-177) protein (Fc Tag)IL19 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in 50 mM acetic acid at 50 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against 50 mM acetic acid.
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Storage
- -80 °C
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Storage Comment
- Lyophilized recombinant mouse Interleukin-19 (rmIL-19) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rmIL-19 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
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Expiry Date
- 6 months
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- IL-19 (IL19) (Interleukin 19 (IL19))
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Alternative Name
- Interleukin-19 (IL-19)
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Background
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Interleukin-19 (IL-19) is a cytokine belonging to the interleukin family. Structurally, IL-19 is grouped into the IL-10 sub-family, which also includes IL-20, IL-22, IL-24, and IL-26. In contrast to IL-10, which exists as a homodimer, IL-19 is stable and active as a monomer in vivo. IL-19 functions through the receptor complex composed of IL-20 Receptor alpha and IL-20 Receptor beta, which is also utilized by IL-20 and IL-24. IL-19 is produced by active monocytes and stimulated synergistically by IL-17 and IL-13. The functions of IL-19 are to promote the development and function of Th2 cells and to enhance the production of Th2 cytokines. IL-19 is implicated in aging, vascular disease, Type I diabetes, and rheumatoid arthritis. Recombinant mouse Interleukin-19 (rmIL-19) produced in E. coli is a single non-glycosylated polypeptide chain containing of153 amino acids. A fully biologically active molecule, rmIL-19 has a molecular mass of 17.7 kDa analyzed by non-reducing SDS-PAGE.
Synonyms: Melanoma differentiation association like protein, MDA1, NG.1, ZMDA1, IL-10C, IL-19 -
Molecular Weight
- 17.7 kDa, observed by non-reducing SDS-PAGE.
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UniProt
- Q8CJ70
Target
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