PF4 Protein (AA 32-101)

Catalog No. ABIN2018316

This Recombinant PF4 protein is produced in HEK-293T Cells.

Quick Overview for PF4 Protein (AA 32-101) (ABIN2018316)

Target: PF4 (Platelet Factor 4 (PF4))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293T Cells

Purity: > 95 % as analyzed by SDS-PAGE and HPLC.

Product Details

Protein Characteristics: AA 32-101

Characteristics: ED50 < 10 μg/mL, measured by its ability to inhibit human FGF-basic-dependent proliferation of NR6R 3T3 mouse fibroblast cells.

Endotoxin Level: < 0.2 EU/μg, determined by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Storage: -80 °C

Storage Comment: Lyophilized recombinant human platelet factor 4 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, human platelet factor 4 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Expiry Date: 6 months

Target Details

Target: PF4 (Platelet Factor 4 (PF4))

Alternative Name: Platelet Factor 4/CXCL4

Background: Platelet factor 4, also known as CXCL4, is expressed in megakaryocytes and stored in the alpha-granules of platelets. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines. Platelet factor 4 can be antiproliferative and antiangiogenic, at least in part via interfering with FGF2 and VEGF heparin binding and thus inhibiting their signaling. However, it can also be proinflammatory and proatherogenic through multiple effects on monocytes, macrophages and endothelial cells.
Synonyms: PF-4, CXCL4, SCYB4,Platelet Factor-4, CXCL4, Oncostatin A, Ironplact

Molecular Weight: -7.8 kDa, observed by non-reducing SDS-PAGE.

UniProt: P02776