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CD3 epsilon Protein (CD3E) (AA 22-117) (His tag)

CD3E Origin: Cynomolgus Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Catalog No. ABIN2180774
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  • Target See all CD3 epsilon (CD3E) Proteins
    CD3 epsilon (CD3E)
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 22-117
    Origin
    • 21
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cynomolgus
    Source
    • 17
    • 8
    • 6
    • 2
    • 2
    • 2
    HEK-293 Cells
    Purification tag / Conjugate
    This CD3 epsilon protein is labelled with His tag.
    Sequence
    AA 22-117
    Characteristics
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 11.7 kDa. The protein migrates as 18-20 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Purity
    >90 % as determined by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    CD3 epsilon (CD3E)
    Alternative Name
    CD3 epsilon (CD3E Products)
    Synonyms
    cd3e, CD3E, t3e, tcre, AI504783, CD3, CD3epsilon, T3e, T3E, TCRE, CD3e molecule, CD3 antigen, epsilon polypeptide, cd3e, CD3E, Cd3e
    Background
    CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
    Molecular Weight
    12.2 kDa
    UniProt
    Q95LI5
    Pathways
    TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
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