CD3 epsilon Protein (CD3E) (AA 23-126) (His tag)
Quick Overview for CD3 epsilon Protein (CD3E) (AA 23-126) (His tag) (ABIN2180778)
Target
See all CD3 epsilon (CD3E) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 23-126
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Purification tag / Conjugate
- This CD3 epsilon protein is labelled with His tag.
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Sequence
- AA 23-126
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Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.2 kDa. The protein migrates as 18-20 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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CD3 epsilon (CD3E) (AA 22-117) (Active) protein (His tag)
CD3E Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE Active
CD3 epsilon (CD3E) (AA 23-48) (Active) protein (hFc-Avi Tag)CD3E Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD3 epsilon (CD3E) (AA 22-48) (Active) protein (hFc-Avi Tag)CD3E Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD3 epsilon (CD3E) (AA 22-48) (Active) protein (hFc-Avi Tag,Biotin)CD3E Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD3 epsilon (CD3E) (AA 23-48) (Active) protein (hFc-Avi Tag,Biotin)CD3E Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD3 epsilon (CD3E) (Active) protein (mFc Tag)CD3E Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE. Active
CD3 epsilon (CD3E) (AA 23-126) protein (His tag,AVI tag,Biotin)CD3E Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
CD3 epsilon (CD3E) (AA 23-207) protein (GST tag)CD3E Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
CD3 epsilon (CD3E) (AA 22-117) protein (Fc Tag)CD3E Origin: Cynomolgus Host: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
CD3 epsilon (CD3E) (AA 23-126) protein (Fc Tag)CD3E Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
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- CD3 epsilon (CD3E)
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Alternative Name
- CD3 epsilon
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Background
- CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
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Molecular Weight
- 12.6 kDa
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NCBI Accession
- NP_000724
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Pathways
- TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
Target
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