EGFR Protein (AA 25-645) (Fc Tag)
(1 reference)-
- Target See all EGFR Proteins
- EGFR (Epidermal Growth Factor Receptor (EGFR))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 25-645
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This EGFR protein is labelled with Fc Tag.
- Sequence
- AA 25-645
- Characteristics
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 95 kDa. The protein migrates as 130-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Purity
- >95 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product EGFR Protein
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Epidermal Growth Factor Receptor (EGFR) (AA 25-645) protein (His-Avi Tag)
EGFR Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epidermal Growth Factor Receptor (EGFR) protein (His-Avi Tag,Biotin)EGFR Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Epidermal Growth Factor Receptor (EGFR) (AA 25-645) protein (Fc Tag)EGFR Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epidermal Growth Factor Receptor (EGFR) (AA 25-645) (Active) protein (His tag,AVI tag,Biotin)EGFR Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Epidermal Growth Factor Receptor (EGFR) (AA 25-378) (Active) protein (His tag,AVI tag,Biotin)EGFR Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Epidermal Growth Factor Receptor (EGFR) (AA 25-645) protein (His tag)EGFR Origin: Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epidermal Growth Factor Receptor (EGFR) (AA 25-647) protein (His tag)EGFR Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epidermal Growth Factor Receptor (EGFR) (AA 1-405) protein (GST tag)EGFR Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Epidermal Growth Factor Receptor (EGFR) (AA 25-645) protein (His tag)EGFR Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Epidermal Growth Factor Receptor (EGFR) (AA 25-645) protein (His tag)EGFR Origin: Cynomolgus Host: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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: "Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients." in: Molecular cancer therapeutics, Vol. 13, Issue 7, pp. 1777-90, (2014) (PubMed).
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: "Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients." in: Molecular cancer therapeutics, Vol. 13, Issue 7, pp. 1777-90, (2014) (PubMed).
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- Target
- EGFR (Epidermal Growth Factor Receptor (EGFR))
- Alternative Name
- EGF R (EGFR Products)
- Background
- The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.
- Molecular Weight
- 94.7 kDa
- NCBI Accession
- NP_005219
- Pathways
- NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins
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