LRRC4 Protein (AA 39-527) (His tag)

Catalog No. ABIN2181482

This Recombinant LRRC4 protein is expressed in HEK-293 Cells.

Quick Overview for LRRC4 Protein (AA 39-527) (His tag) (ABIN2181482)

Target: LRRC4 (Leucine Rich Repeat Containing 4 (LRRC4))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: >92 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 39-527

Purification tag / Conjugate: This LRRC4 protein is labelled with His tag.

Sequence: AA 39-527

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.6 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Target Details

Target: LRRC4 (Leucine Rich Repeat Containing 4 (LRRC4))

Alternative Name: LRRC4

Background: LRRC4 (Leu-rich repeat/LRR-containing glycoprotein 4), LRRC4B and LRRC4C are post-synaptic adhesion molecules of the LRR protein family that induce excitatory synapse formation. LRRC4 is also known as Brain tumor-associated protein BAG, Netrin-G2 ligand (NGL-2), Nasopharyngeal carcinoma-associated gene 14 protein (NAG14), which contains 1 Ig-like (immunoglobulin-like) domain and 9 LRR (leucine-rich) repeats, 1 LRRCT domain, 1 LRRNT domain. LRRC4 / NGL-2 specifically expressed in brain. LRRC4 / NGL-2 regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. LRRC4 / NGL-2 organize the lamina/pathway-specific differentiation of dendrites. LRRC4 / NGL-2 plays a important role for auditory synaptic responses and involved in the suppression of glioma.

Molecular Weight: 55.8 kDa

Pathways: Synaptic Membrane