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ROR1 Protein (Receptor Tyrosine Kinase-Like Orphan Receptor 1) (AA 30-403) (His tag)

ROR1 Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Catalog No. ABIN2181701
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  • Target See all ROR1 Proteins
    ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 30-403
    Origin
    • 31
    • 8
    • 8
    • 7
    • 3
    • 1
    • 1
    Mouse
    Source
    • 26
    • 7
    • 5
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This ROR1 protein is labelled with His tag.
    Sequence
    AA 30-403
    Characteristics
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 42.6 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Purity
    >95 % as determined by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 0.1 EU per μg by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Target
    ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))
    Alternative Name
    ROR1 (ROR1 Products)
    Synonyms
    NTRKR1, dJ537F10.1, 2810404D04Rik, Ntrkr1, mRor1, RGD1559469, ROR1, fi34e02, si:dkey-209n16.1, wu:fi34e02, receptor tyrosine kinase like orphan receptor 1, receptor tyrosine kinase-like orphan receptor 1, ROR1, Ror1, ror1
    Background
    Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
    Molecular Weight
    42.9 kDa
    UniProt
    Q9Z139
    Pathways
    RTK Signaling, WNT Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
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