ROR1 Protein (AA 165-305) (His tag)

Catalog No. ABIN7275526

This Recombinant ROR1 protein is expressed in HEK-293 Cells.

Quick Overview for ROR1 Protein (AA 165-305) (His tag) (ABIN7275526)

Target: ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human, Cynomolgus, Rhesus Monkey

Source: HEK-293 Cells

Purity: > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC

Product Details

Protein Characteristics: AA 165-305

Purification tag / Conjugate: This ROR1 protein is labelled with His tag.

Purpose: Human/Cynomolgus/Rhesus macaque ROR1 (165-305, Frizzled Domain) Protein

Sequence: Glu165-Asp305

Characteristics: Recombinant Human/Cynomolgus/Rhesus macaque ROR1 (165-305, Frizzled Domain) Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu165-Asp305.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Human/Cynomolgus/Rhesus macaque ROR1 (165-305, Frizzled Domain) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,The purity of Human/Cynomolgus/Rhesus macaque ROR1 (165-305, Frizzled Domain) is greater than 95% as determined by SEC-HPLC.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))

Alternative Name: ROR1

Background: ROR1 (Receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1),  is a member of  the ROR family within receptor tyrosine kinases (RTK) superfamily. Two ROR family members (ROR1 and ROR2) have been identified and are characterized by the intracellular tyrosine kinase domains, highly related to those of the Trk-family receptor tyrosine kinases, and by the extracellular Frizzled-like cysteine-rich domains and kringle domains, which are common to receptors of the Wnt family members.

Molecular Weight: 17 kDa. Due to glycosylation, the protein migrates to 18-24 kDa based on Bis-Tris PAGE result.

UniProt: Q01973

Pathways: RTK Signaling, WNT Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha