ADIPOQ Protein
Quick Overview for ADIPOQ Protein (ABIN2468217)
Target
See all ADIPOQ ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- RGHHHHHHHH VTTTEELAPA LVPPPKGTCA GWMAGIPGHP GHNGTPGRDG RDGTPGEKGE KGDAGLLGPK GETGDVGMTG AEGPRGFPGT PGRKGEPGEA AYVYRSAFSV GLETRVTVPN VPIRFTKIFY NQQNHYDGST GKFYCNIPGL YYFSYHITVY MKDVKVSLFK KDKAVLFTYD QYQEKNVDQA SGSVLLHLEV GDQVWLQVYG DGDHNGLYAD NVNDSTFTGF LLYHDTN
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Characteristics
- Determined by a cytotoxic assay using M1 cells. The ED50 for this effect is 4.0-6.0 μg/mL.
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Adiponectin (ADIPOQ) (Active) protein
ADIPOQ Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Adiponectin (ADIPOQ) (AA 19-244) protein (His tag)ADIPOQ Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Adiponectin (ADIPOQ) (AA 18-247) protein (His tag)ADIPOQ Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Adiponectin (ADIPOQ) (AA 19-244) protein (Fc Tag)ADIPOQ Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Adiponectin (ADIPOQ) (AA 18-247) protein (Fc Tag)ADIPOQ Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Adiponectin (ADIPOQ) protein (His tag)ADIPOQ Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Adiponectin (ADIPOQ) (AA 111-247) protein (His tag)ADIPOQ Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Adiponectin (ADIPOQ) (AA 111-210) protein (GST tag)ADIPOQ Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Adiponectin (ADIPOQ) (AA 111-247) proteinADIPOQ Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS - PAGE SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Handling Advice
- As with any protein, exposing Adiponectin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Storage
- -20 °C
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Storage Comment
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Adiponectin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
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Expiry Date
- 24 months
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- ADIPOQ (Adiponectin (ADIPOQ))
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Alternative Name
- Adiponectin
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Background
- Adiponectin is an adipose-derived secreted protein containing 236 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01 % of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-beta and class A scavenger receptor in macrophages). Recombinant adiponectin is a multimeric glycoprotein containing amino acids Val-18 to Asn-247 of the adiponectin precursor protein fused to an N-terminal histidine tag. Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 25.9 kDa by SDS PAGE analysis under reducing conditions.
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Gene ID
- 11450
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NCBI Accession
- NP_033735
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OMIM
- 87252711
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UniProt
- Q60994
Target
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