APOA1 Protein (His tag)
Quick Overview for APOA1 Protein (His tag) (ABIN2566290)
Target
See all APOA1 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This APOA1 protein is labelled with His tag.
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Characteristics
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Immobilized Human ApoAI at 10 μg/mL (100 μL/well) can bind biotinylated human SCARB1. The EC50 of biotinylated human SCARB1 is 10-100 ng/mL.
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Apolipoprotein A-I (APOA1) (AA 25-267) (Active) protein (hFc Tag)
APOA1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Apolipoprotein A-I (APOA1) (AA 25-264) (Active) protein (hFc Tag)APOA1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Apolipoprotein A-I (APOA1) (AA 1-267) protein (GST tag)APOA1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Apolipoprotein A-I (APOA1) (AA 25-267) protein (His tag)APOA1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
- This recombinant protein can be used for WB. For research use only.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -80 °C,-20 °C
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Storage Comment
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
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- APOA1 (Apolipoprotein A-I (APOA1))
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Alternative Name
- Apo A1
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Background
- ApoA1 is also known as apolipoprotein A-I, ApoA-I , and is the major protein component of high density lipoprotein (HDL) in plasma. It has a specific role in lipid metabolism. Chylomicrons secreted from the intestinal enterocyte also contain ApoA1 but it is quickly transferred to HDL in the bloodstream. The protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. In addition, it has been shown that ApoA1 is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.
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Molecular Weight
- 29 kDa
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Gene ID
- 335
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NCBI Accession
- NP_000030
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UniProt
- P02647
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Pathways
- Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response, Lipid Metabolism
Target
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