Protein A Protein

Catalog No. ABIN2648105

Native Protein A protein expressed in Staphylococcus aureus.

Quick Overview for Protein A Protein (ABIN2648105)

Target: Protein A

Protein Type: Native

Origin: Staphylococcus aureus

Source: Staphylococcus aureus

Purity: > 95 % pure

Product Details

Characteristics: Immunoglobulin-binding bacterial Protein A solution
Protein Source: Staphylococcus aureus

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Supplied as a lyophilized powder.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Aliquot and store at -20 °C.

Target Details

Target: Protein A

Background: Protein A is a 40-60 kDa MSCRAMM surface protein originally found in the cell wall of the bacteria Staphylococcus aureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two-component system called ArlS-ArlR. It has found use in biochemical research because of its ability to bind immunoglobulins. It binds proteins from many of mammalian species, most notably IgGs. It binds with the Fc region of immunoglobulins through interaction with the heavy chain. The result of this type of interaction is that, in serum, the bacteria will bind IgG molecules in the wrong orientation (in relation to normal antibody function) on their surface which disrupts opsonization and phagocytosis.
Description: Staphylococcus aureus.