DNMT1 Protein (AA 2-1632) (GST tag)
Quick Overview for DNMT1 Protein (AA 2-1632) (GST tag) (ABIN2669604)
Target
See all DNMT1 ProteinsProtein Type
Biological Activity
Origin
Source
Application
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Protein Characteristics
- AA 2-1632
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Purification tag / Conjugate
- This DNMT1 protein is labelled with GST tag.
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Characteristics
- Recombinant human DNMT1 was expressed in Sf9 cells via a baculovirus expression system as amino acids 2-1632 (accession number NM_001130823) with an N-terminal GST tag. The molecular weight of the protein is 211 kDa.
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DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-1620) protein (His tag)
custom-made DNMT1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-1616) protein (His tag)custom-made DNMT1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (AA 1-110) protein (GST tag)DNMT1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (Transcript Variant 1) (Active) protein (Myc-DYKDDDDK Tag)DNMT1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, Func, PI, STD Active
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Application Notes
- Recombinant DNMT1 is suitable for use in DNA methylation assays. This protein is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
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Restrictions
- For Research Use only
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Handling Advice
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
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Alternative Name
- DNMT1
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Background
- DNMT1 - DNA methyltransferase 1 (or DNMT 1) proteins are involved in DNA methylation in which a methyl group is added to a cytosine residue on DNA, commonly at the C5 position of a CpG dinucleotide. Three families of DNMTs have been identified: DNMT1, DNMT2, and DNMT3 (comprised of DNMT3A and DNMT3B). DNMT1 is the most abundant DNMT in somatic cells and shows a preference for methylating hemi-methylated DNA. It is considered to be a maintenance DNA methyltransferase that is important in the maintenance of specific patterns of methylation throughout cellular divisions. Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as embryonic development, genetic imprinting, X chromosome inactivation and the control of gene expression. DNA methylation is generally associated with transcriptional repression.
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Molecular Weight
- The molecular weight of the protein is 211 kDa.
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Pathways
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Target
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