ASH1L Protein (AA 2407-2579) (His tag,DYKDDDDK Tag)
This Recombinant ASH1L protein is expressed in Escherichia coli (E. coli).
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Catalog No. ABIN2669693
$616.92
Plus shipping costs $50.00, if applicable $20.00 dry ice
100 μg
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United States
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Quick Overview for ASH1L Protein (AA 2407-2579) (His tag,DYKDDDDK Tag) (ABIN2669693)
Target
ASH1L
(Ash1 (Absent, Small, Or Homeotic)-like (ASH1L))
Protein Type
Recombinant
Origin
Human
Source
Escherichia coli (E. coli)
Application
Binding Studies (Bind), Screening Assay (ScA)
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Protein Characteristics
- AA 2407-2579
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Purification tag / Conjugate
- This ASH1L protein is labelled with His tag,DYKDDDDK Tag.
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Characteristics
- The peptide corresponding to amino acids 2407-2579 that contains the bromodomain sequences of ASH1L (accession number NP_060959.2) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag with an observed molecular weight of 25.6 kDa.
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Ash1 (Absent, Small, Or Homeotic)-like (ASH1L) (AA 2433-2548) protein (His-IF2DI Tag)
ASH1L Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
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Application Notes
- Recombinant ASH1L (2407-2579) is suitable for use in binding assays, inhibitor screening, and selectivity profiling.
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Restrictions
- For Research Use only
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Handling Advice
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- ASH1L (Ash1 (Absent, Small, Or Homeotic)-like (ASH1L))
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Alternative Name
- ASH1L
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Background
- ASH1L is a member of the Trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. The bromodomain functions as a 'reader' of epigenetic histone marks and regulates chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. ASH1L is localized to the nucleus and also to cell-cell tight junctions where it is hypothesized to function in adhesion-mediated signaling. ASH1L functions in methylation of H3K4 and regulation of expression of HOX genes and may possess methyltransferase activity directed at H3K36. ASH1L has also been implicated in facioscapulohumeral muscular dystrophy.
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Molecular Weight
- 25.6 kDa
Target
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