ERCC5 Protein (Myc-DYKDDDDK Tag)
Quick Overview for ERCC5 Protein (Myc-DYKDDDDK Tag) (ABIN2712283)
Target
See all ERCC5 ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This ERCC5 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human ERCC5 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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DNA Repair Protein Complementing XP-G Cells (ERCC5) (AA 1-1170) protein (His tag)
custom-made ERCC5 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
DNA Repair Protein Complementing XP-G Cells (ERCC5) (AA 1-1186) protein (His tag)custom-made ERCC5 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))
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Alternative Name
- Ercc5
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Background
- This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
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Molecular Weight
- 133.1 kDa
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NCBI Accession
- NP_000114
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Pathways
- DNA Damage Repair
Target
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