ABI1 Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2714282

Recombinant ABI1 protein expressed in HEK-293 Cells.

Quick Overview for ABI1 Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag) (ABIN2714282)

Target: ABI1 (Abl-Interactor 1 (ABI1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant 4

Purification tag / Conjugate: This ABI1 protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human ABI1 / SSH3BP1 (transcript variant 4) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: ABI1 (Abl-Interactor 1 (ABI1))

Alternative Name: Abi1,ssh3bp1

Background: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(1011) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.

Molecular Weight: 51.7 kDa

NCBI Accession: NP_001012770

Pathways: RTK Signaling, Response to Water Deprivation, ER-Nucleus Signaling