Ensa Protein (Transcript Variant 8) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2714623

This Recombinant Ensa protein is expressed in HEK-293 Cells.

Quick Overview for Ensa Protein (Transcript Variant 8) (Myc-DYKDDDDK Tag) (ABIN2714623)

Target: Ensa (ENSA) (Endosulfine alpha (ENSA))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant 8

Purification tag / Conjugate: This Ensa protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human Alpha-endosulfine / ENSA (transcript variant 8) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: Ensa (ENSA) (Endosulfine alpha (ENSA))

Alternative Name: alpha-Endosulfine (Ensa)

Background: The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.

Molecular Weight: 11.8 kDa

NCBI Accession: NP_997051